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Protease transition state inhibitor prodrugs
Chang, Kyeong-Ok Groutas, William C.
Chang, Kyeong-Ok
Groutas, William C.
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WO/2018/023054
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2018-02-01
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Chang, K., Groutas, W.C., inventors; Wichita State University, Kansas State University Research Foundation, assignees. Protease transition state inhibitor prodrugs. World Intellectual Property Organization WO/2018/023054. 2018, February 1.
Abstract
Disclosed herein are protease transition state inhibitor/analogue prodrug compounds selected from the group consisting of esters, carbamates, ester phosphates, and pharmaceutically acceptable salts thereof. Compositions containing such prodrugs are also disclosed, along with methods of using such compounds therapeutically or prophylactically against calicivirus, picornavirus, and/or coronavirus infection, as well as other conditions, such as malaria, cancer, stroke, heart attack, neural degeneration, cataracts, and glaucoma through inhibition of the variety of proteases associated with progression of such conditions.
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WSU inventor: Groutas, William C., Dept. of Chemistry, College of Liberal Arts and Sciences
International Application No: PCT/US2017/044485 filed July 28, 2017. Patent No: WO/2018/023054 granted February 1, 2018.
International Application No: PCT/US2017/044485 filed July 28, 2017. Patent No: WO/2018/023054 granted February 1, 2018.
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World Intellectual Property Organization
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Status: Publication 2018-02-01