Potent inhibition of Norwalk virus by cyclic sulfamide derivatives
Dou, Dengfeng Tiew, Kok-Chuan He, Guijia Mandadapu, Sivakoteswara Rao Aravapalli, Sridhar Alliston, Kevin R. Kim, Yunjeong Chang, Kyeong-Ok Groutas, William C.
Dou, Dengfeng
Tiew, Kok-Chuan
He, Guijia
Mandadapu, Sivakoteswara Rao
Aravapalli, Sridhar
Alliston, Kevin R.
Kim, Yunjeong
Chang, Kyeong-Ok
Groutas, William C.
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Original Date
Digitization Date
Issue Date
2011-10-15
Type
Article
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Keywords
Research Support, N.I.H., Extramural
Subjects (LCSH)
Citation
Bioorganic & medicinal chemistry. 2011 Oct 15; 19(20): 5975-83.
Abstract
A new class of compounds that exhibit anti-norovirus activity in a cell-based system and embody in their structure a cyclosulfamide scaffold has been identified. The structure of the initial hit (compound 2a, ED(50) 4 µM, TD(50) 50 µM) has been prospected by exploiting multiple points of diversity and generating appropriate structure-activity relationships.
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Publisher
Elsevier
Journal
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Series
Bioorganic & medicinal chemistry
Bioorg. Med. Chem.
Bioorg. Med. Chem.
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NLM
PubMed ID
DOI
ISSN
1464-3391
0968-0896
0968-0896