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Broad spectrum antivirals against coronavirus
Chang, Kyeong-Ok Kim, Yunjeong Groutas, William C. Perlman, Stanley
Chang, Kyeong-Ok
Kim, Yunjeong
Groutas, William C.
Perlman, Stanley
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2023-05-18
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Patent
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Chang, K., Kim, Y., Groutas, W.C., & Perlman, S., inventors; Wichita State University, Kansas State University Research Foundation, University Of Iowa Research Foundation, assignees. Broad spectrum antivirals against coronavirus. United States patent US 20230150933 A1. 2023, May 18.
Abstract
Compounds exhibiting antiviral activity and/or inhibition of viral replication against viruses, particularly those belonging to the picornavirus-like supercluster, including coronavirus having a formula: (I) where X comprises a cyclic moiety, R$_2$ is a branched or unbranched alkyl, cycloalkyl, aryl, arylalkyl, alkenyl, alkynyl, amino acid side chain, bicyclic or tricyclic side chain, combinations, and substituted forms thereof, and Z is selected from the group consisting of C$_1$-C$_6$ hydroxyalkyl, aldehydes, alpha-ketoamides, and bisulfite salts, and in particular -CH$_2$OH, -CHO, -CH(0H)S0$_3$$^-$Na$^+$, and -[0(C=0)R$_w$]S0$_3$$^-$Na$^+$.
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WSU inventor: Groutas, William C., Dept. of Chemistry, College of Liberal Arts and Sciences
Application No: 17/907745 filed March 30, 2021. Patent No: US 20230150933 A1 granted May 18, 2023.
Application No: 17/907745 filed March 30, 2021. Patent No: US 20230150933 A1 granted May 18, 2023.
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United States Patent and Trademark Office
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Status: Pending