Use of the 1,2,5-thiadiazolidin-3-one 1,1 dioxide and isothiazolidin-3-one 1,1 dioxide scaffolds in the design of potent inhibitors of serine proteinases
Kuang, Rongze Venkataraman, Radhika Ruan, Sumei Groutas, William C.
Kuang, Rongze
Venkataraman, Radhika
Ruan, Sumei
Groutas, William C.
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1998-03-03
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Article
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Research Support, Non-U.S. Gov't,Research Support, U.S. Gov't, P.H.S.
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Citation
Bioorganic & medicinal chemistry letters. 1998 Mar 3; 8(5): 539-44.
Abstract
The attachment of a phosphate leaving group to the 1,2,5-thiadiazolidin-3-one 1,1 dioxide and isothiazolidin-3-one 1,1 dioxide scaffolds was found to yield highly potent, time-dependent inhibitors of human leukocyte elastase (HLE).
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Full text of this article is not available in SOAR.
Publisher
Elsevier
Journal
Bioorganic and Medicinal Chemistry Letters
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NLM
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ISSN
0960-894X