Structural Insight on Supramolecular Polyion Salts: Inositol Hexaphosphate Enclosed in Cationic Macrocyclic Clusters
Pramanik, Subhamay Steinert, Ryan M. Mitchell-Koch, Katie R. Bowman-James, Kristin
Pramanik, Subhamay
Steinert, Ryan M.
Mitchell-Koch, Katie R.
Bowman-James, Kristin
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2023-08
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Article
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Keywords
Bioanions,Crystal structure,Macrocycles,Phytate,Supramolecular
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Citation
Pramanik, S., Steinert, R.M., Mitchell-Koch, K.R., & Bowman-James, K. (2023). Structural Insight on Supramolecular Polyion Salts: Inositol Hexaphosphate Enclosed in Cationic Macrocyclic Clusters. Chemistry - A European Journal. https://doi.org/10.1002/chem.202301764
Abstract
Supramolecular macrocyclic forces have been used to trap phytate, myo-inositol-1,2,3,4,5,6-hexakisphosphate, a key bioanion with multiple roles in metabolic processes. Due to the complex chemistry of six multivalent phosphates surrounding the small, cyclic inositol framework, crystallographic information of simple phytate salts has been elusive. This report represents a combined crystallographic, theoretical, and solution binding investigation of a supramolecular macrocyclic complex of phytate. Together, the results provide significant insight to phytate's intramolecular and intermolecular interactions at the microenvironment level. The macrocycle-phytate aggregates consist of phytate anionic pairs, each partly sandwiched by two 24-membered, amide/amine-based cationic macrocycles. The phytate ion pairs hold the tetrameric macrocyclic array together by six strong intermolecular hydrogen bonds. Both phytates crystallize in 1a5e phosphate conformations (one axial (P2) and five equatorial phosphates). Solution NMR binding studies in 1 : 1 DMSO-$d_{6}$ : D$_{2}$O indicate 2 : 1 macrocycle:phytate associations, suggesting that the sandwich-like nature of the complex holds together in solution. DFT studies indicate the likely occurrence of dynamic intramolecular interchange of phosphate protons, as well as important roles for the axial (P2) phosphate in both intramolecular and intermolecular hydrogen bonding interactions.
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John Wiley and Sons Inc
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Chemistry - A European Journal
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0947-6539