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Investigation of intrinsically disordered regions in the Drosophila matrisome
Kasirosafar, Nazanin Kabir, Md Wasi Ul Hoque, Md Tamjidul
Kasirosafar, Nazanin
Kabir, Md Wasi Ul
Hoque, Md Tamjidul
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2025-04-25
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Kasirosafar, Nazanin; Kabir, Md Wasi Ul; Hoque, Md Tamjidul. 2025. Investigation of intrinsically disordered regions in the Drosophila matrisome. -- In Proceedings: 24th Annual Undergraduate Research and Creative Activity Forum. Wichita, KS: Wichita State University, p. 8
Abstract
Organ formation is associated with large-scale motion dynamics within the embryo. The protein network that supports cells—Extracellular Matrix (ECM)—has been studied as a passive substrate that functions exclusively to support cell motion and tissue organization. To form tissues and organs, however, embryos need to transport the ECM along with cells as a tissue composite. Although some studies have shown motile ECM in the context of embryogenesis, the material properties that confer ECM with these dynamic roles are poorly understood. Taking a multidisciplinary approach, we test the hypothesis that certain components of the embryonic ECM have fluid-like material properties and may show the potential to form biocondensates as a result of their structural properties. As a starting point for testing our hypothesis, we systematically screened the Drosophila matrisome using a computational framework to rank proteins containing intrinsically disordered regions (IDRs). Our computational screening identified at least 30 Drosphila matrisome components with high-confidence IDRs, some of which show robust embryonic expression. Ongoing studies examine the biological roles of Fondue, one of these ECM components that exhibit IDRs with high confidence scores.
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Presented to the 24th Undergraduate Research and Creative Activity Forum (URCAF) held in Woolsey Hall, Wichita State University, April 25, 2025.
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Wichita State University
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URCAF;v.24