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The Drosophila developmental ionome—a metal ion transporter perspective
Neupane, Prabriti
Neupane, Prabriti
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2025-05
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The Drosophila gene Malvolio (Mvl) encodes for a metal ion transporter. Hence, Mvl can be used to study the metal ion transporter physiology. Mvl is used for the cellular uptake of iron, copper, and manganese. Due to its role in transporting multiple cations, Mvl belongs to a category of proteins that are called multispecific transporters. A loss of Mvl is thus expected to cause an imbalance in the elemental composition (ionome) of developing organs. The aim of my research is to quantify the physiological impact of Mvl on systematic elemental homeostasis. I have tested the hypothesis that loss of Mvl function results in abnormal ionome composition. The hypothesis is tested by quantifying whole and tissue-specific Drosophila ionomes. Surprisingly, the study found that there was no significant difference between the genotypes in the levels of Fe (wildtype Vs. Mvl mutant). However, there was a significant difference in the levels of Mn between Oregon R and one of the Mvl mutant alleles $(Mvl^{exc1}).$ Similarly, Cu was significantly different between Oregon R and both mutant alleles tested $(Mvl^{exc1}$ and $Mvl^{m13}).$ Additional testing is required to explain why Mn and Cu levels are increased in the Mvl mutants compared to the wildype.
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Thesis (M.S.)-- Wichita State University, College of Liberal Arts and Sciences, Dept. of Biological Sciences
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Wichita State University
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