BIO Faculty Publications

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    Stem cell-based therapy for Parkinson's disease
    (Springer Nature, 2024-03-26) Brice, Ryan; Sai, Haneesha Vishwa; Tran, Kimmy; Garcia, Jade; Ramirez, Edwyne; Yao, Li
    Parkinson's disease (PD) is a primary neurodegenerative disease that can cause neuronal degeneration leading to disability. The continuing loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc) leads to progressive degeneration. Although considerable research has been conducted on this disease, the lost neuron function cannot be satisfactorily recovered. Current therapeutic methods are primarily focused on symptomatic treatment. It is a great challenge to prevent disease progression. The advancement of stem cell research has raised a promising alternative approach for treating PD. This chapter reviews the pathophysiological process of this disease and summarizes the concept and advances in stem cell research as a novel therapeutic option for PD. © Springer Nature Singapore Pte Ltd. 2024. All rights reserved.
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    Comment on “Atlas of Fshr Expression From Novel Reporter Mice”
    (Endocrine Society, 2025-04-03) Casarini, Livio; Rahman, Nafis; Reiter, Eric; Crépieux, Pascale; Rivero-Müller, Adolfo; Jonas, Kim C.; Kumar, T. Rajendra; Ulloa-Aguirre, Alfredo; Franks, Stephen; Bernard, Daniel J.; Kristensen, Stine G.; Davis, John S.; Bousfield, George R.; Dias, James A; Andersen, Claus Y.; Handelsman, David J.; Huhtaniemi, Ilpo; Simoni, Manuela
    [No abstract available]
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    Scarabaeidae: Rutelinae
    (CRC Press) Ramirez-Ponce, A.; Paucar-Herman, A.; Jameson, Mary Liz; Jameson, Mary Liz
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    Glaresidae
    (CRC Press) Keller, Oliver; Jameson, Mary Liz; Jameson, Mary Liz
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    Significant progress in stem cell treatment for Alzheimer's disease: A critical review
    (CRC Press, 2025) Petkova, Karina; Neupane, Prabriti; Schmitt, Sarah; Neupane, Nischal; Loganathan, Rajprasad; Yao, Li; Loganathan, Rajprasad; Yao, Li
    This handbook comprehensively explores various facets of stem cells and their secretome in the field of regenerative medicine, covering topics such as the biology, characteristics, and applications of mesenchymal and non-mesenchymal stem cells in diverse medical contexts. It delves into their potential for treatment of radiation injuries, diabetes, aging-related diseases, osteoarthritis, Alzheimer's disease, and oral surgery. Furthermore, it investigates the potential of neuronal stem cells for neural repair, myoblast implants for Duchenne muscular dystrophy, and immunotherapy using non-genetically modified natural killer cells. The book also uncovers the possibilities of botanical leads for stem cell therapy, explores the role of stem cells in promoting healthy aging, and sheds light on their complex interplay with cancer, particularly in gliomas and gynecologic cancers. Additionally, it reviews the use of stem cell-derived insoluble factors, focusing on extracellular vesicles as therapeutic agents in dentistry, cardiovascular diseases, and neurodegenerative disorders. The chapters discuss the potential of engineering mesenchymal stem cells secretome for bone regeneration and treating intracerebral hemorrhage. Towards the end, the book elucidates cell-free scaffolding for tissue engineering, adult stem cells' disease tropism, and the evolving strategies in regenerative medicine. It is intended for researchers, professionals, and academicians in the fields of regenerative medicine, stem cell biology, and medical biotechnology.