Browsing by Subject "N-glycosylation"
Now showing items 1-3 of 3
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Evaluation of in vivo bioactivities of recombinant hypo- (FSH21/18) and fully- (FSH24) glycosylated human FSH glycoforms in Fshb null mice
(Elsevier, Ireland LTD, 2016-12-05)The hormone - specific FSH beta subunit of the human FSH heterodimer consists of N-linked glycans at Asn(7) and Asn(24) residues that are co-translationally attached early during subunit biosynthesis. Differences in the ... -
A human FSHB transgene encoding the double N-glycosylation mutant (Asn(7 Delta) Asn(24 Delta)) FSH beta subunit fails to rescue Fshb null mice
(Elsevier B.V., 2016-05-05)Follicle-stimulating hormone (FSH) is a gonadotrope-derived heterodimeric glycoprotein. Both the common alpha and hormone-specific beta subunits contain Asn-linked N-glycan chains. Recently, macro heterogeneous FSH glycoforms ... -
In vivo and in vitro impact of carbohydrate variation on human follicle-stimulating hormone function
(Frontiers Media S.A., 2018-05-09)Human follicle-stimulating hormone (FSH) exhibits both macro-and microheterogeneity in its carbohydrate moieties. Macroheterogeneity results in three physiologically relevant FSH beta subunit variants, two that possess a ...