Browsing by Author "Dampalla, Chamandi S."
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Structure-guided design of conformationally constrained cyclohexane inhibitors of severe acute respiratory syndrome coronavirus-2 3cl protease
Dampalla, Chamandi S.; Kim, Yunjeong; Bickmeier, Naemi; Rathnayake, Athri D. (American Chemical Society, 2021-07-01)A series of nondeuterated and deuterated dipeptidyl aldehyde and masked aldehyde inhibitors that incorporate in their structure a conformationally constrained cyclohexane moiety was synthesized and found to potently inhibit ... -
Structure-guided design of potent inhibitors of SARS-CoV-2 3CL protease: Structural, biochemical, and cell-based studies
Dampalla, Chamandi S.; Rathnayake, Athri D.; Perera, Krishani Dinali; Jesri, Abdul Rahman M.; Nguyen, Harry Nhat; Miller, Matthew J.; Thurman, Hayden A.; Zheng, Jian; Kashipathy, Maithri M.; Battaile, Kevin P.; Lovell, Scott; Perlman, Stanley (American Chemical Society, 2021-12-01)The COVID-19 pandemic is having a major impact on public health worldwide, and there is an urgent need for the creation of an armamentarium of effective therapeutics, including vaccines, biologics, and small-molecule ... -
Structure-guided optimization of dipeptidyl inhibitors of Norovirus 3CL protease
Rathnayake, Athri D.; Kim, Yunjeong; Dampalla, Chamandi S.; Nguyen, Harry Nhat; Jesri, Abdul Rahman M.; Kashipathy, Maithri M.; Lushington, Gerald Henry; Battaile, Kevin P.; Lovell, Scott; Chang, Kyeong-Ok; Groutas, William C. (American Chemical Society, 2020-09-18)Acute gastroenteritis caused by noroviruses has a major impact on public health worldwide in terms of morbidity, mortality, and economic burden. The disease impacts most severely immunocompromised patients, the elderly, ...