Browsing by Author "Dampalla, Chamandi S."

Now showing items 1-5 of 5

    • Broad-spectrum cyclopropane-based inhibitors of coronavirus 3C-like proteases: Biochemical, structural, and virological studies 

      Dampalla, Chamandi S.; Nguyen, Harry Nhat; Rathnayake, Athri D.; Kim, Yunjeong; Perera, Krishani Dinali; Madden, Trent K.; Thurman, Hayden A.; Machen, Alexandra J.; Kashipathy, Maithri M.; Liu, Lijun; Battaile, Kevin P.; Lovell, Scott; Chang, Kyeong-Ok; Groutas, William C. (American Chemical Society, 2022-12-28)
      The advent of SARS-CoV-2, the causative agent of COVID-19, and its worldwide impact on global health, have provided the impetus for the development of effective countermeasures that can be deployed against the virus, ...

    • Structure-guided design of conformationally constrained cyclohexane inhibitors of severe acute respiratory syndrome coronavirus-2 3cl protease 

      Dampalla, Chamandi S.; Kim, Yunjeong; Bickmeier, Naemi; Rathnayake, Athri D. (American Chemical Society, 2021-07-01)
      A series of nondeuterated and deuterated dipeptidyl aldehyde and masked aldehyde inhibitors that incorporate in their structure a conformationally constrained cyclohexane moiety was synthesized and found to potently inhibit ...

    • Structure-guided design of potent inhibitors of SARS-CoV-2 3CL protease: Structural, biochemical, and cell-based studies 

      Dampalla, Chamandi S.; Rathnayake, Athri D.; Perera, Krishani Dinali; Jesri, Abdul Rahman M.; Nguyen, Harry Nhat; Miller, Matthew J.; Thurman, Hayden A.; Zheng, Jian; Kashipathy, Maithri M.; Battaile, Kevin P.; Lovell, Scott; Perlman, Stanley (American Chemical Society, 2021-12-01)
      The COVID-19 pandemic is having a major impact on public health worldwide, and there is an urgent need for the creation of an armamentarium of effective therapeutics, including vaccines, biologics, and small-molecule ...

    • Structure-guided design of potent spirocyclic inhibitors of severe acute respiratory syndrome coronavirus-2 3C-like protease 

      Dampalla, Chamandi S.; Rathnayake, Athri D.; Galasiti Kankanamalage, Anushka C.; Kim, Yunjeong; Perera, Krishani Dinali; Nguyen, Harry Nhat; Miller, Matthew J.; Madden, Trent K.; Picard, Hunter R.; Thurman, Hayden A.; Kashipathy, Maithri M.; Liu, Lijun; Battaile, Kevin P.; Lovell, Scott; Chang, Kyeong-Ok; Groutas, William C. (American Chemical Society, 2022-06-09)
      The worldwide impact of the ongoing COVID-19 pandemic on public health has made imperative the discovery and development of direct-acting antivirals aimed at targeting viral and/or host targets. SARS-CoV-2 3C-like protease ...

    • Structure-guided optimization of dipeptidyl inhibitors of Norovirus 3CL protease 

      Rathnayake, Athri D.; Kim, Yunjeong; Dampalla, Chamandi S.; Nguyen, Harry Nhat; Jesri, Abdul Rahman M.; Kashipathy, Maithri M.; Lushington, Gerald Henry; Battaile, Kevin P.; Lovell, Scott; Chang, Kyeong-Ok; Groutas, William C. (American Chemical Society, 2020-09-18)
      Acute gastroenteritis caused by noroviruses has a major impact on public health worldwide in terms of morbidity, mortality, and economic burden. The disease impacts most severely immunocompromised patients, the elderly, ...