Now showing items 1-4 of 4

    • Amino acid-derived 1,2-benzisothiazolinone derivatives as novel small-molecule antifungal inhibitors: identification of potential genetic targets 

      Alex, Deepu; Gay-Andrieu, Francoise; May, Jared; Thampi, Linta; Dou, Dengfeng; Mooney, Aileen; Groutas, William C.; Calderone, Richard (American Society of Microbiology, 2012-09)
      We have identified four synthetic compounds (DFD-VI-15, BD-I-186, DFD-V-49, and DFD-V-66) from an amino acid-derived 1,2-benzisothiazolinone (BZT) scaffold that have reasonable MIC50 values against a panel of fungal ...
    • Antifungal activity of a series of 1,2-benzisothiazol-3(2H)-one derivatives 

      Dou, Dengfeng; Alex, Deepu; Du, Bingfan; Tiew, Kok-Chuan; Aravapalli, Sridhar; Mandadapu, Sivakoteswara Rao; Calderone, Richard; Groutas, William C. (Elsevier, 2011-10-01)
      A series of broad-spectrum antifungal agents based on the 1,2-benzisothiazol-3(2H)-one scaffold is reported. Preliminary structure-activity relationship studies have established the importance of the presence of the ...
    • Antifungal drug discovery: the process and outcomes 

      Calderone, Richard; Sun, Nuo; Gay-Andrieu, Francoise; Groutas, William C.; Weerawarna, Pathum M.; Prasad, Sridhar; Alex, Deepu; Li, Dongmei (Future Medicine Ltd, 2014-06)
      New data suggest that the global incidence of several types of fungal diseases have traditionally been under- documented. Of these, mortality caused by invasive fungal infections remains disturbingly high, equal to or ...
    • Repurposing an inhibitor of ribosomal biogenesis with broad anti-fungal activity 

      Sun, Nuo; Li, Dongmei; Zhang, Yuhan; Killeen, Kyle; Groutas, William C.; Calderone, Richard (Nature Publishing Group, 2017-12-05)
      The lack of new antifungal compounds with unique mechanisms of action is a concern for therapeutic management of patients. To identify inhibitors against human pathogenic fungi, we screened similar to 3000 compounds provided ...