Cardiac hormones are c-Jun-N-Terminal Kinase 2-inhibiting peptides
Lane, Meghan L.
Frost, Chelsea D.
Nguyen, Jennifer P.
Skelton, William P.
Vesely, David L.
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Lane M.L., Santana O., Frost C.D., Guerrero J., Skelton M., et al. 2012. "Cardiac hormones are c-Jun-N-terminal kinase 2-inhibiting peptides". Anticancer Research. 32 (3): 721-725
Background: Four cardiac peptide hormones, namely vessel dilator, long-acting natriuretic peptide (LANP), kaliuretic peptide, and atrial natriuretic peptide (ANP) have anticancer effects. Materials and Methods: The effects of these four cardiac hormones on human c-Jun-N-terminal kinase 2 (JNK2) were examined in human small cell lung cancer and human prostate cancer cells. Results: Vessel dilator, LANP, kaliuretic peptide and ANP maximally reduced expression of JNK2 by 89%, 56%, 45%, and 28%, respectively (each at p<0.0001) in human small cell lung cancer cells. In human prostate adenocarcinoma cells, JNK2 was maximally decreased 76%, 56%, 45%, (each at p<0.0001), and 28% (p<0.01) secondary to vessel dilator, LANP, kaliuretic peptide and ANP, respectively. Conclusion: These results indicate that four cardiac hormones are significant inhibitors (by up to 89%) of JNK2 in human small cell lung cancer cells and up to 76% in human prostate adenocarcinoma cells as part of their anticancer mechanism(s) of action.
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