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dc.contributorWichita State University. Department of Physical Therapyen_US
dc.contributor.authorSmith, Barbara S.en_US
dc.date.accessioned2012-03-12T19:12:55Z
dc.date.available2012-03-12T19:12:55Z
dc.date.issued1989-12en_US
dc.identifier2623650en_US
dc.identifier0153257en_US
dc.identifier.citationTeratology. 1989 Dec; 40(6): 641-6.en_US
dc.identifier.issn0040-3709en_US
dc.identifier.urihttp://dx.doi.org/10.1002/tera.1420400611en_US
dc.identifier.urihttp://hdl.handle.net/10057/4809
dc.descriptionClick on the DOI link below to access the article (may not be free).en_US
dc.description.abstractTrisomy 1 embryos consistently show eye defects (e.g., aphakia, microphakia, retention of lens stalk). To determine if the plane of division of mitotic figures is abnormal in the eyes of these animals, trisomic embryos (9.5 through 12 gestational days) were produced from mice doubly heterozygous for Robertsonian translocation chromosomes [Rb(1.3)/Rb(1.10)]. To accommodate for the known delay in trisomic embryo development, animals were grouped according to stages of eye development rather than to gestational age. Serial sections were evaluated without knowledge of karyotype for orientation of mitotic figures (parallel, perpendicular, oblique) in lens, optic cup, and diencephalon. Location of mitotic figures was scored as apical (nearest the lumen), middle, and basal. Numerous anomalies were noted in trisomic eye development. No difference was found between orientation of mitotic figures in the lens and optic cup of trisomy 1 and normal embryos. Location of mitotic figures in trisomy 1 lens was significantly different from that of normal littermates. The data confirm earlier studies that trisomy 1 affects the eye, and they tend to corroborate evidence that this trisomy affects the lens more than it affects the optic cup.en_US
dc.format.extent641-6en_US
dc.language.isoengen_US
dc.publisherJohn Wiley & Sonsen_US
dc.relation.ispartofseriesTeratologyen_US
dc.relation.ispartofseriesTeratologyen_US
dc.sourceNLMen_US
dc.subjectResearch Support, Non-U.S. Gov'ten_US
dc.subject.meshAnimalsen_US
dc.subject.meshEye/cytologyen_US
dc.subject.meshLens, Crystalline/anatomy & histologyen_US
dc.subject.meshMiceen_US
dc.subject.meshMitosisen_US
dc.subject.meshMitotic Spindle Apparatus/physiologyen_US
dc.subject.meshTrisomyen_US
dc.titleMitosis in embryonic trisomy 1 mouse eyeen_US
dc.typeArticleen_US
dc.coverage.spacialUnited Statesen_US
dc.description.versionpeer revieweden_US
dc.rights.holderCopyright © 1989 Wiley-Lissen_US


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