Mitosis in embryonic trisomy 1 mouse eye

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dc.contributor Wichita State University. Department of Physical Therapy en_US
dc.contributor.author Smith, Barbara S. en_US
dc.date.accessioned 2012-03-12T19:12:55Z
dc.date.available 2012-03-12T19:12:55Z
dc.date.issued 1989-12 en_US
dc.identifier 2623650 en_US
dc.identifier 0153257 en_US
dc.identifier.citation Teratology. 1989 Dec; 40(6): 641-6. en_US
dc.identifier.issn 0040-3709 en_US
dc.identifier.uri http://dx.doi.org/10.1002/tera.1420400611 en_US
dc.identifier.uri http://hdl.handle.net/10057/4809
dc.description Click on the DOI link below to access the article (may not be free). en_US
dc.description.abstract Trisomy 1 embryos consistently show eye defects (e.g., aphakia, microphakia, retention of lens stalk). To determine if the plane of division of mitotic figures is abnormal in the eyes of these animals, trisomic embryos (9.5 through 12 gestational days) were produced from mice doubly heterozygous for Robertsonian translocation chromosomes [Rb(1.3)/Rb(1.10)]. To accommodate for the known delay in trisomic embryo development, animals were grouped according to stages of eye development rather than to gestational age. Serial sections were evaluated without knowledge of karyotype for orientation of mitotic figures (parallel, perpendicular, oblique) in lens, optic cup, and diencephalon. Location of mitotic figures was scored as apical (nearest the lumen), middle, and basal. Numerous anomalies were noted in trisomic eye development. No difference was found between orientation of mitotic figures in the lens and optic cup of trisomy 1 and normal embryos. Location of mitotic figures in trisomy 1 lens was significantly different from that of normal littermates. The data confirm earlier studies that trisomy 1 affects the eye, and they tend to corroborate evidence that this trisomy affects the lens more than it affects the optic cup. en_US
dc.format.extent 641-6 en_US
dc.language.iso eng en_US
dc.publisher John Wiley & Sons en_US
dc.relation.ispartofseries Teratology en_US
dc.relation.ispartofseries Teratology en_US
dc.source NLM en_US
dc.subject Research Support, Non-U.S. Gov't en_US
dc.subject.mesh Animals en_US
dc.subject.mesh Eye/cytology en_US
dc.subject.mesh Lens, Crystalline/anatomy & histology en_US
dc.subject.mesh Mice en_US
dc.subject.mesh Mitosis en_US
dc.subject.mesh Mitotic Spindle Apparatus/physiology en_US
dc.subject.mesh Trisomy en_US
dc.title Mitosis in embryonic trisomy 1 mouse eye en_US
dc.type Article en_US
dc.coverage.spacial United States en_US
dc.description.version peer reviewed en_US
dc.rights.holder Copyright © 1989 Wiley-Liss en_US

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