Show simple item record

dc.contributorWichita State University. Department of Public Health Sciencesen_US
dc.contributor.authorCarter, John W.en_US
dc.contributor.authorLancaster, Hugh K.en_US
dc.contributor.authorHardman, W. Elaineen_US
dc.contributor.authorCameron, Ivan L.en_US
dc.date.accessioned2012-03-07T17:40:09Z
dc.date.available2012-03-07T17:40:09Z
dc.date.issued1997en_US
dc.identifier9101549en_US
dc.identifier7905040en_US
dc.identifierT32 AG-00165en_US
dc.identifier.citationNutrition and cancer. 1997; 27(3): 217-21.en_US
dc.identifier.issn0163-5581en_US
dc.identifier.urihttp://dx.doi.org/10.1080/01635589709514529en_US
dc.identifier.urihttp://hdl.handle.net/10057/4754
dc.descriptionClick on the DOI link below to access the article (may not be free).en_US
dc.description.abstractThe aim of this study was to characterize colon tumor development and invasiveness associated with dietary zinc deprivation. Colon carcinogenesis was initiated by eight weekly subcutaneous injections of 1,2-dimethylhydrazine (DMH) at 12 mg DMH base/kg body wt in groups of mice maintained on diets containing 30 micrograms/kg dietary zinc (zinc adequate, ZA) or 3 micrograms/kg dietary zinc (zinc deprived, ZD). All mice were killed 24 weeks after the last injection of DMH. Mean zinc concentration in the liver was significantly lower in the ZD group than in the ZA group. The total number of grossly detectable colon tumors was the same in both dietary groups. However, histopathological study of each tumor revealed significantly more adenomatous polyps (AP) and invasive adenocarcinomas (CA) in the ZA group, whereas the ZD group had significantly more noninvasive carcinomas in situ (CIS). It appears that zinc deprivation stimulated progression of AP to noninvasive CIS but retarded the progression of noninvasive CIS to invasive CA. Immunohistochemistry of tumors from ZA and ZD mice indicated increased amounts of type IV collagenase in epithelial tumor cells and in stromal cells adjacent to tumor tissue regardless of the amount of dietary zinc consumed. It is suggested that zinc deprivation may limit function of zinc-requiring enzymes such as superoxide dismutase and type IV collagenase, resulting in enhanced progression of AP to noninvasive CIS and retardation of invasion of CIS to become CA, respectively.en_US
dc.description.sponsorshipNIA NIH HHSen_US
dc.format.extent217-21en_US
dc.language.isoengen_US
dc.publisherRoutledgeen_US
dc.relation.ispartofseriesNutrition and Canceren_US
dc.relation.ispartofseriesNutr Canceren_US
dc.sourceNLMen_US
dc.subjectResearch Support, Non-U.S. Gov'ten_US
dc.subjectResearch Support, U.S. Gov't, Non-P.H.S.en_US
dc.subjectResearch Support, U.S. Gov't, P.H.S.en_US
dc.subject.mesh1,2-Dimethylhydrazineen_US
dc.subject.meshAdenocarcinoma/chemically induceden_US
dc.subject.meshAnimalsen_US
dc.subject.meshBody Weighten_US
dc.subject.meshCarcinogensen_US
dc.subject.meshCarcinoma in Situ/chemically induceden_US
dc.subject.meshCollagenases/analysisen_US
dc.subject.meshColon/pathologyen_US
dc.subject.meshColonic Neoplasms/chemically induceden_US
dc.subject.meshDieten_US
dc.subject.meshDimethylhydrazinesen_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshLiver/chemistryen_US
dc.subject.meshMaleen_US
dc.subject.meshMatrix Metalloproteinase 9en_US
dc.subject.meshMiceen_US
dc.subject.meshNeoplasm Invasivenessen_US
dc.subject.meshOrgan Sizeen_US
dc.subject.meshZinc/administration & dosageen_US
dc.subject.meshAdenocarcinoma/pathologyen_US
dc.subject.meshCarcinoma in Situ/pathologyen_US
dc.subject.meshCollagenases/metabolismen_US
dc.subject.meshColonic Neoplasms/pathologyen_US
dc.subject.meshZinc/analysisen_US
dc.subject.meshZinc/deficiencyen_US
dc.titleZinc deprivation promotes progression of 1,2-dimethylhydrazine-induced colon tumors but reduces malignant invasion in miceen_US
dc.typeArticleen_US
dc.coverage.spacialUnited Statesen_US
dc.description.versionpeer revieweden_US
dc.rights.holderCopyright © Routledgeen_US


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record