Numerical simulations of pulsatile flow in an end-to-side anastomosis model

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dc.contributor Wichita State University. Department of Aerospace Engineering
dc.contributor.author Shaik, Eleyas
dc.contributor.author Hoffmann, Klaus A.
dc.contributor.author Dietiker, JF.
dc.date.accessioned 2012-02-10T21:49:35Z
dc.date.available 2012-02-10T21:49:35Z
dc.date.issued 2007-03
dc.identifier.citation Shaik E, KA Hoffmann, and JF Dietiker. 2007. "Numerical simulations of pulsatile flow in an end-to-side anastomosis model". Molecular & Cellular Biomechanics : MCB. 4 (1): 41-53. en_US
dc.identifier.issn 1556-5297
dc.identifier.issn 1556-5300
dc.identifier.uri http://hdl.handle.net/10057/4453
dc.identifier.uri http://dx.doi.org/10.3970/mcb.2007.004.041
dc.description Click on the DOI link below to access the article(may not be free) en_US
dc.description.abstract A potential interaction between the local hemodynamics and the artery wall response has been suggested for vascular graft failure by intimal hyperplasia (IH). Among the various hemodynamic factors, wall shear stress has been implicated as the primary factor responsible for the development of IH. In order to explore the role of hemodynamics in the formation of IH in end-to-side anastomosis, computational fluid dynamics is employed. To validate the numerical simulations, comparisons with existing experimental data are performed for both steady and pulsatile flows. Generally, good agreement is observed with the velocity profiles whereas some discrepancies are found in wall shear stress (WSS) distributions. Using the same end-to-side anastomosis geometry, numerical simulations are extended using a femoral artery waveform to identify the possible role of unsteady hemodynamics. In the current simulations, Carreau-Yasuda model is used to account for the non-Newtonian nature of blood. Computations indicated a disturbed flow field at the artery-graft junction leading to locally elevated shear stresses on the vascular wall. Furthermore, the shear stress distribution followed the same behavior with oscillating magnitude over the entire flow cycle. Thus, distal IH observed in end-to-side artery-graft models may be caused by the fluctuations in WSS's along the wall. en_US
dc.language.iso en_US en_US
dc.publisher Tech Science Press en_US
dc.relation.ispartofseries Molecular & Cellular Biomechanics;2007:, v.4, no.1
dc.subject Artery bypass en_US
dc.subject Computational fluid dynamics en_US
dc.subject End-to-side anastomosis en_US
dc.subject Hemodynamics en_US
dc.subject Intimal hyperplasia en_US
dc.title Numerical simulations of pulsatile flow in an end-to-side anastomosis model en_US
dc.type Article en_US
dc.description.version Peer reviewed
dc.rights.holder Copyright © 2007, Tech Science Press

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