Progesterone downregulates progesterone receptor, but not estrogen receptor, in the estrogen-primed oviduct of a turtle (Trachemys scripta)

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dc.contributor.author Selcer, Kyle W. en_US
dc.contributor.author Leavitt, Wendell W. en_US
dc.date.accessioned 2012-01-24T17:50:39Z
dc.date.available 2012-01-24T17:50:39Z
dc.date.issued 1991-08 en_US
dc.identifier 1916218 en_US
dc.identifier 0370735 en_US
dc.identifier.citation General and comparative endocrinology. 1991 Aug; 83(2): 316-23. en_US
dc.identifier.issn 0016-6480 en_US
dc.identifier.uri http://dx.doi.org/10.1016/0016-6480(91)90036-6
dc.identifier.uri http://hdl.handle.net/10057/4211
dc.description Click on the DOI link below to access the article (may not be free). en_US
dc.description.abstract Progesterone downregulates nuclear progesterone receptor (Rp) and estrogen receptor (Re) in the estrogen-primed mammalian uterus and chick oviduct. We sought to determine if this downregulation mechanism is operative in the turtle oviduct. Female turtles were primed for 4 days with 17-beta-estradiol, after which progesterone (5 mg) was administered by injection every 24 h. Re and Rp levels in progesterone-treated and control turtle oviducts were measured by [3H]steroid-binding assays (pyridoxal 5' phosphate method) at 12, 24, 48 and 72 hr after initial progesterone treatment. Serum progesterone levels of progesterone-treated turtles increased only slightly from 0 hr (0.3 ng/ml) to 12 hr (0.6 ng/ml) after progesterone administration, increased considerably by 24 hr (5.3 ng/ml), and remained elevated (6-8 ng/ml) through 72 hr. Cytosol and nuclear Rp levels of estrogen-primed turtle oviducts showed distinct seasonal variation, with Rp levels higher in spring and summer months than in winter months. There was no seasonal variation in Re levels. Both cytosol and nuclear Rp responded to progesterone treatment. Cytosol Rp levels of progesterone-treated oviducts were significantly reduced below control levels by 12 hr after progesterone administration and remained low through 72 hr. Nuclear Rp levels of progesterone-treated oviducts showed no change at 12 hr, increased at 24 hr and then dropped at 48 and 72 hr. However, progesterone did not downregulate Re in the turtle oviduct. en_US
dc.language.iso eng en_US
dc.relation.ispartofseries General and comparative endocrinology en_US
dc.source NLM en_US
dc.subject Comparative Study en_US
dc.subject Research Support, U.S. Gov't, Non-P.H.S. en_US
dc.subject.mesh Animals en_US
dc.subject.mesh Cell Nucleus/metabolism en_US
dc.subject.mesh Cytosol/metabolism en_US
dc.subject.mesh Down-Regulation/drug effects en_US
dc.subject.mesh Drug Implants en_US
dc.subject.mesh Estradiol/metabolism en_US
dc.subject.mesh Female en_US
dc.subject.mesh Kinetics en_US
dc.subject.mesh Oviducts/drug effects en_US
dc.subject.mesh Progesterone/pharmacology en_US
dc.subject.mesh Receptors, Estrogen/drug effects en_US
dc.subject.mesh Receptors, Progesterone/drug effects en_US
dc.subject.mesh Turtles/physiology en_US
dc.subject.mesh Estradiol/pharmacology en_US
dc.subject.mesh Oviducts/metabolism en_US
dc.subject.mesh Receptors, Estrogen/metabolism en_US
dc.subject.mesh Receptors, Progesterone/metabolism en_US
dc.title Progesterone downregulates progesterone receptor, but not estrogen receptor, in the estrogen-primed oviduct of a turtle (Trachemys scripta) en_US
dc.type Article en_US
dc.description.version peer reviewed en_US
dc.rights.holder Copyright © 1991, Elsevier en_US

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