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dc.contributor.authorSelcer, Kyle W.en_US
dc.contributor.authorLeavitt, Wendell W.en_US
dc.date.accessioned2012-01-24T17:50:39Z
dc.date.available2012-01-24T17:50:39Z
dc.date.issued1991-08en_US
dc.identifier1916218en_US
dc.identifier0370735en_US
dc.identifier.citationGeneral and comparative endocrinology. 1991 Aug; 83(2): 316-23.en_US
dc.identifier.issn0016-6480en_US
dc.identifier.urihttp://dx.doi.org/10.1016/0016-6480(91)90036-6
dc.identifier.urihttp://hdl.handle.net/10057/4211
dc.descriptionClick on the DOI link below to access the article (may not be free).en_US
dc.description.abstractProgesterone downregulates nuclear progesterone receptor (Rp) and estrogen receptor (Re) in the estrogen-primed mammalian uterus and chick oviduct. We sought to determine if this downregulation mechanism is operative in the turtle oviduct. Female turtles were primed for 4 days with 17-beta-estradiol, after which progesterone (5 mg) was administered by injection every 24 h. Re and Rp levels in progesterone-treated and control turtle oviducts were measured by [3H]steroid-binding assays (pyridoxal 5' phosphate method) at 12, 24, 48 and 72 hr after initial progesterone treatment. Serum progesterone levels of progesterone-treated turtles increased only slightly from 0 hr (0.3 ng/ml) to 12 hr (0.6 ng/ml) after progesterone administration, increased considerably by 24 hr (5.3 ng/ml), and remained elevated (6-8 ng/ml) through 72 hr. Cytosol and nuclear Rp levels of estrogen-primed turtle oviducts showed distinct seasonal variation, with Rp levels higher in spring and summer months than in winter months. There was no seasonal variation in Re levels. Both cytosol and nuclear Rp responded to progesterone treatment. Cytosol Rp levels of progesterone-treated oviducts were significantly reduced below control levels by 12 hr after progesterone administration and remained low through 72 hr. Nuclear Rp levels of progesterone-treated oviducts showed no change at 12 hr, increased at 24 hr and then dropped at 48 and 72 hr. However, progesterone did not downregulate Re in the turtle oviduct.en_US
dc.language.isoengen_US
dc.relation.ispartofseriesGeneral and comparative endocrinologyen_US
dc.sourceNLMen_US
dc.subjectComparative Studyen_US
dc.subjectResearch Support, U.S. Gov't, Non-P.H.S.en_US
dc.subject.meshAnimalsen_US
dc.subject.meshCell Nucleus/metabolismen_US
dc.subject.meshCytosol/metabolismen_US
dc.subject.meshDown-Regulation/drug effectsen_US
dc.subject.meshDrug Implantsen_US
dc.subject.meshEstradiol/metabolismen_US
dc.subject.meshFemaleen_US
dc.subject.meshKineticsen_US
dc.subject.meshOviducts/drug effectsen_US
dc.subject.meshProgesterone/pharmacologyen_US
dc.subject.meshReceptors, Estrogen/drug effectsen_US
dc.subject.meshReceptors, Progesterone/drug effectsen_US
dc.subject.meshTurtles/physiologyen_US
dc.subject.meshEstradiol/pharmacologyen_US
dc.subject.meshOviducts/metabolismen_US
dc.subject.meshReceptors, Estrogen/metabolismen_US
dc.subject.meshReceptors, Progesterone/metabolismen_US
dc.titleProgesterone downregulates progesterone receptor, but not estrogen receptor, in the estrogen-primed oviduct of a turtle (Trachemys scripta)en_US
dc.typeArticleen_US
dc.description.versionpeer revieweden_US
dc.rights.holderCopyright © 1991, Elsevieren_US


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