Serum corticosteroid-binding globulin (CBG) and hepatic CBG mRNA relationships during hamster pregnancy: contribution of decidualization

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dc.contributor.author Selcer, Kyle W. en_US
dc.contributor.author Lin, Guang-Xiong en_US
dc.contributor.author Beale, Elmus G. en_US
dc.contributor.author Leavitt, Wendell W. en_US
dc.date.accessioned 2012-01-24T17:49:24Z
dc.date.available 2012-01-24T17:49:24Z
dc.date.issued 1991-01 en_US
dc.identifier 2015348 en_US
dc.identifier HD18712 en_US
dc.identifier 0207224 en_US
dc.identifier.citation Biology of reproduction. 1991 Jan; 44(1): 185-90. en_US
dc.identifier.issn 0006-3363 en_US
dc.identifier.uri http://www.biolreprod.org/content/44/1/185.full.pdf
dc.identifier.uri http://hdl.handle.net/10057/4164
dc.description Click on the link below to access the article (may not be free). en_US
dc.description.abstract We measured serum corticosteroid-binding globulin (CBG) and hepatic CBG mRNA from individual hamsters throughout pregnancy and during decidualization. Serum CBG levels were determined by 3H-cortisol binding assay, and hepatic CBG mRNA levels were measured by Northern blots and solution hybridization assays, using a 32P-labeled cRNA probe derived from a rat CBG cDNA. There was a positive relationship between hepatic CBG mRNA levels and serum CBG levels during pregnancy. Both parameters increased significantly from the time of mating (cycle Day 4) to pregnancy Day 4, showing that CBG synthesis and secretion increased prior to implantation (Day 4). After implantation, serum CBG and hepatic CBG mRNA rose further from pregnancy Day 4 to a peak on Day 14, then decreased before parturition on Day 16. The prepartum decline in hepatic CBG mRNA preceded the fall in serum CBG. Decidualization on pseudopregnancy Day 4 resulted in an increase in serum CBG and hepatic CBG mRNA. Hepatic CBG mRNA increased from Day 5 to Day 7, and serum CBG increased progressively from Day 5 through Day 9 after uterine decidualization in the hamster. The present results demonstrate that the pattern of serum CBG observed in the pregnant hamster follows closely that of hepatic CBG mRNA. A signal emanating from uterine decidual tissue appears to be important in the regulation of hepatic CBG synthesis and secretion during midpregnancy, but other unknown factors appear to be involved in controlling CBG during the early and late stages of pregnancy. en_US
dc.description.sponsorship NICHD NIH HHS en_US
dc.language.iso eng en_US
dc.publisher Society for the Study of Reproduction en_US
dc.relation.ispartofseries Biology of reproduction en_US
dc.source NLM en_US
dc.subject Research Support, U.S. Gov't, P.H.S. en_US
dc.subject.mesh Animals en_US
dc.subject.mesh Blotting, Northern en_US
dc.subject.mesh Cricetinae en_US
dc.subject.mesh Decidua/metabolism en_US
dc.subject.mesh Female en_US
dc.subject.mesh Liver/metabolism en_US
dc.subject.mesh Mesocricetus en_US
dc.subject.mesh Nucleic Acid Hybridization en_US
dc.subject.mesh Pregnancy en_US
dc.subject.mesh RNA, Messenger/genetics en_US
dc.subject.mesh Transcortin/metabolism en_US
dc.subject.mesh RNA, Messenger/metabolism en_US
dc.subject.mesh Transcortin/genetics en_US
dc.title Serum corticosteroid-binding globulin (CBG) and hepatic CBG mRNA relationships during hamster pregnancy: contribution of decidualization en_US
dc.type Article en_US
dc.description.version peer reviewed en_US

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