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dc.contributor.authorSelcer, Kyle W.en_US
dc.contributor.authorLin, Guang-Xiongen_US
dc.contributor.authorBeale, Elmus G.en_US
dc.contributor.authorLeavitt, Wendell W.en_US
dc.date.accessioned2012-01-24T17:49:24Z
dc.date.available2012-01-24T17:49:24Z
dc.date.issued1991-01en_US
dc.identifier2015348en_US
dc.identifierHD18712en_US
dc.identifier0207224en_US
dc.identifier.citationBiology of reproduction. 1991 Jan; 44(1): 185-90.en_US
dc.identifier.issn0006-3363en_US
dc.identifier.urihttp://www.biolreprod.org/content/44/1/185.full.pdf
dc.identifier.urihttp://hdl.handle.net/10057/4164
dc.descriptionClick on the link below to access the article (may not be free).en_US
dc.description.abstractWe measured serum corticosteroid-binding globulin (CBG) and hepatic CBG mRNA from individual hamsters throughout pregnancy and during decidualization. Serum CBG levels were determined by 3H-cortisol binding assay, and hepatic CBG mRNA levels were measured by Northern blots and solution hybridization assays, using a 32P-labeled cRNA probe derived from a rat CBG cDNA. There was a positive relationship between hepatic CBG mRNA levels and serum CBG levels during pregnancy. Both parameters increased significantly from the time of mating (cycle Day 4) to pregnancy Day 4, showing that CBG synthesis and secretion increased prior to implantation (Day 4). After implantation, serum CBG and hepatic CBG mRNA rose further from pregnancy Day 4 to a peak on Day 14, then decreased before parturition on Day 16. The prepartum decline in hepatic CBG mRNA preceded the fall in serum CBG. Decidualization on pseudopregnancy Day 4 resulted in an increase in serum CBG and hepatic CBG mRNA. Hepatic CBG mRNA increased from Day 5 to Day 7, and serum CBG increased progressively from Day 5 through Day 9 after uterine decidualization in the hamster. The present results demonstrate that the pattern of serum CBG observed in the pregnant hamster follows closely that of hepatic CBG mRNA. A signal emanating from uterine decidual tissue appears to be important in the regulation of hepatic CBG synthesis and secretion during midpregnancy, but other unknown factors appear to be involved in controlling CBG during the early and late stages of pregnancy.en_US
dc.description.sponsorshipNICHD NIH HHSen_US
dc.language.isoengen_US
dc.publisherSociety for the Study of Reproductionen_US
dc.relation.ispartofseriesBiology of reproductionen_US
dc.sourceNLMen_US
dc.subjectResearch Support, U.S. Gov't, P.H.S.en_US
dc.subject.meshAnimalsen_US
dc.subject.meshBlotting, Northernen_US
dc.subject.meshCricetinaeen_US
dc.subject.meshDecidua/metabolismen_US
dc.subject.meshFemaleen_US
dc.subject.meshLiver/metabolismen_US
dc.subject.meshMesocricetusen_US
dc.subject.meshNucleic Acid Hybridizationen_US
dc.subject.meshPregnancyen_US
dc.subject.meshRNA, Messenger/geneticsen_US
dc.subject.meshTranscortin/metabolismen_US
dc.subject.meshRNA, Messenger/metabolismen_US
dc.subject.meshTranscortin/geneticsen_US
dc.titleSerum corticosteroid-binding globulin (CBG) and hepatic CBG mRNA relationships during hamster pregnancy: contribution of decidualizationen_US
dc.typeArticleen_US
dc.description.versionpeer revieweden_US


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