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Browsing CHEM Theses and Dissertations by Issue Date

Browsing CHEM Theses and Dissertations by Issue Date

Now showing items 1-20 of 47

The chemistry of L-ascorbic acid derivatives in the asymmetric synthesis of C2- and C3-substituted aldono-gamma-lactones

Olabisi, Ayodele O. (2005-08)

The antioxidant and redox properties of L-ascorbic acid are closely associated with the electron rich 2, 3-enediol moiety of the molecule and therefore selective functionalization of the 2- and 3-OH groups is essential for ...
Cyano-substituted polypyrazolylborate metal complexes

Zhao, Ningfeng (2005-12)

Polypyrazolylborates have become one of the most popular ligands used in inorganic and organometallic chemistry. Because of the electron-withdrawing and potential coordination property of the cyano group, as well as the ...
Novel mechanism-based inhibitors of serine proteases

Gan, Xiangdong (2005-12)

The design and in vitro biochemical evaluation of two novel classes of mechanism-based inhibitors of human leukocyte elastase (HLE) that inactivate the enzyme via an unprecedented enzyme-induced sulfonamide fragmentation ...
Development of a method to investigate intra-molecular proton migration during collision induced dissociation of gas-phase peptides

Wu, Qun (2005-12)

Use of a combination of hydrogen/deuterium (H/D) exchange, mass spectrometry (MS) and/or CID is a rapidly evolving approach to the investigation of protein structure and conformation and the dynamics of conformational ...
Supramolecular porphyrin-fullerene conjugates: design, synthesis, electrochemical and photochemical studies

Gadde, Suresh (2006-05)

The research reported in this thesis details the synthesis, characterization, electrochemical and photochemical studies of noncovalently linked porphyrin-fullerene based donor-acceptor systems. The first chapter gives an ...
Synthesis of neutral anion receptor 5,10-bis-(2-(4-fluorophenyl)phenylurea)-15,20-diphenylporphyrin and its characterization

Calderon-Kawasaki, Kenichi E. (2006-05)

Binding studies were performed with a bisurea-picket porphyrin host receptor (a,a)-5,10- Bis-(2-(4-fuorophenyl)phenylurea)-15,20-diphenylporphyrin (1a) and TBA salts as its guest. Previously our group reported1 on the ...
Studies on electron and energy transfer in porphyrin and fullerene based systems

Smith, Phillip M. (2006-05)

The research presented in this thesis deals with the synthesis, optical and photochemical studies of various porphyrin and/or fullerene based systems. The second chapter deals with the study of fullerene based molecules ...
Novel inhibitors of human leukocyte proteinase 3

Du, Bingfan (2006-05)

Chronic obstructive pulmonary disease (COPD) is a multifactorial disorder that is associated with an influx of macrophages, neutrophils and T-lymphocytes to the lungs and the extracellular release of several proteases, ...
Influence of 2 fluorohistidine on pore formation in the anthrax protective antigen

Zhou, Haiying (2006-07)

Bacillus anthracis secretes a toxin which consists of three proteins that is the cause of the anthrax disease symptoms leading to death. They are called the protective antigen (PA), edema factor (EF) and lethal factor (LF). ...
Chemical characterization and two-step cure kinetics of a high performance epoxy adhesive system

Flores, Joel D. (Wichita State University, 2006-07)

The cure kinetics of a high performance epoxy adhesive system based on TGDDM/DGEBA/DDS/DICY and toughened with carboxy terminated poly(acrylonitrile-co-butadiene) rubber with aluminum filler was investigated using differential ...
A new class of carbamoylating agents based on the cyclosulfamide scaffold

Yang, Qingliang (2006-12)

The neutrophil-derived serine proteases human leukocyte elastase (HLE) and proteinase 3 (PR3) have been implicated in various inflammatory diseases such as pulmonary emphysema, chronic bronchitis, asthma, cystic fibrosis, ...
Diimine complexes of ruthenium(ii), rhenium(i) and iron(ii): from synthesis to DFT studies

Kirgan, Robert A. (Wichita State University, 2007-08)

The chloro and pyridinate derivatives of rhenium(I) tricarbonyl complexes containing the diimine ligands 2,2’-bipyrazine (bpz) and 5,5’-dimethyl-2,2’-bipyrazine (Me2bpz) are discussed. When compared to similar rhenium(I) ...
Studies on self-assembled porphyrin-fullerene and porphyrin-carbon nanotube donor-acceptor conjugates

Chitta, Raghu (Wichita State University, 2007-12)

The research presented in this dissertation deals with the syntheses, characterization, electrochemical and photophysical studies of porphyrin-fullerene or porphyrin-carbon nanotube based donor-acceptor conjugates. The ...
Investigation of uranium and various ligand complexes in the gas phase using electrospray ionization ion trap mass spectrometry

Chien, Wen-Fang Winnie (Wichita State University, 2007-12)

The speciation and reactivity of uranium is a topic of sustained interest because species dependent chemistry controls processes ranging from nuclear fuel processing to mobility and fate in the geological surface. Past ...
Modeling the active sites of metalloenzymes with thiolate coordination

Moore, Curtis E. (Wichita State University, 2007-12)

Nitrile Hydratase (NHase) is a bacterial enzyme which catalyzes the hydrolysis of organic nitriles to their corresponding amides. The active site of NHase contains Fe (III) or Co(III) ions in an unusual coordination sphere ...
Oxoporphyrinogens: Electrochemistry, anion binding, and light induced electron transfer studies

Schumacher, Amy Lea (Wichita State University, 2007-12)

The research presented in this dissertation deals with the electrochemical, anion binding and photochemical studies of various oxoporphyrinogen systems. The first chapter provides a brief introduction to the material ...
Proof of concept for the synthesis of [3.4.3.4] metacyclophane using a porphyrin as a scaffold

Jayne, Charles L. (Wichita State University, 2008-05)

Several endo- and exo- cyclophanes of various annulus sizes have been synthesized in the past without the benefit of a template and yields were considered moderate to good. The yields of the exo- cyclophanes were better ...
The influence of cation and “alternative” amino acids on the fragmentation pathways of metal cationized and protonated peptides

Ochola, Sila O. (Wichita State University, 2008-05)

Tandem mass spectrometry and collision-induced dissociation (CID) are the “workhorse” methods for protein identification in proteomics investigations. Recent studies have demonstrated significant differences in the CID ...
Mechanism-based inactivation of humam neutrophil elastase

Li, Yi (Wichita State University, 2008-12)

Chronic obstructive pulmonary disease (COPD) is a major health problem that affects 16 million people in the US, and is currently the fourth most common cause of death. Although the pathogenesis of COPD is poorly understood, ...
Part I: Characterization of Zn reconstituted Cytochrome B561 Part II: Studies of Catecholamine metabolism in SH-SY5Y and MN9D cells

Hewawitharana, Inoka Samanthi (Wichita State University, 2009-05)

Cytochrome b561, a transmembrane heme protein present in neurotransmitter storage vesicles, shuttles electrons from the cytosolic Asc to the intragranullar matrix to regenerate Asc. Although Cyt b561 has been purified, ...