Now showing items 1-20 of 385

  • 1,2,5-Thiadiazolidin-3-one 1,1 dioxide: a powerful scaffold for probing the S' subsites of (chymo)trypsin-like serine proteases 

    Groutas, William C.; Epp, Jeffrey B.; Kuang, Rongze; Ruan, Sumei; Chong, Lee S.; Venkataraman, Radhika; Tu, Juan; He, Shu; Yu, Hongyi; Fu, Qingfong; Li, Yue He; Truong, Tien M.; Vu, Nga T. (Elsevier, 2001-01-01)
    The 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold (I) embodies a motif that allows it to dock to the active site of (chymo)trypsin-like proteases in a predictable and substrate-like fashion. Consequently, inhibitors ...
  • 1,2,5-Thiadiazolidin-3-one 1,1-dioxide-based heterocyclic sulfides are potent inhibitors of human tryptase 

    Wong, Tzutshin; Groutas, Christopher S.; Mohan, Swathi; Lai, Zhong; Alliston, Kevin R.; Vu, Nga T.; Schechter, Norman M.; Groutas, William C. (Elsevier, 2005-04-01)
    We describe herein the design, synthesis, and in vitro biochemical evaluation of a series of potent, time-dependent inhibitors of the mast cell-derived serine protease tryptase. The inhibitors were readily obtained by ...
  • 19F-NMR studies on anthrax toxin protective antigen 

    Chadegani, Fatemeh (Wichita State University, 2014-07)
    The anthrax protective antigen (PA) is a 83 kDa protein that is one of three protein components of the anthrax toxin, an AB toxin (two-component protein complexes secreted by a number of pathogenic bacteria) secreted by ...
  • 2-Fluoro-l-histidine 

    Andra, Kiran K.; Bullinger, John C.; Bann, James G.; Eichhorn, David M. (International Union of Crystallography, 2010-01-01)
    The title compound, C(6)H(8)FN(3)O(2), an analog of histidine, shows a reduced side-chain pK(a) (ca 1). The title structure exhibits a shortening of the bond between the proximal ring N atom and the F-substituted ring C ...
  • 3-(Alkylthio)-N-hydroxysuccinimide derivatives: potent inhibitors of human leukocyte elastase 

    Groutas, William C.; Venkataraman, Radhika; Brubaker, Michael J.; Epp, Jeffrey B.; Chong, Lee S.; Stanga, Michael A.; McClenahan, Jerald J.; Tagusagawa, F. (Elsevier, 1993-08-07)
    A series of 3-(alkylthio)-N-hydroxysuccinimide derivatives was synthesized and their inhibitory activity towards human leukocyte elastase (HLE) was investigated. The interaction of the compounds having a 3-alkylthioether ...
  • 3S-fluoroproline as a probe to monitor proline isomerization during protein folding by 19F-NMR 

    Thomas, Colin A.; Talaty, Erach R.; Bann, James G. (Royal Society of Chemistry, 2009-06-21)
    Variable-temperature inversion transfer NMR is used to determine the kinetic and thermodynamic parameters of cis-trans isomerization of N-Ac-(3R) and (3S)-fluoroproline-OMe.
  • 4-oxocyclohexadienylidene porphyrinogen as an electrochemical anion receptor 

    Schumacher, Amy Lea; D'Souza, Francis (Wichita State University. Graduate School., 2007-04-27)
    Sensitive and selective detection of biologically and environmentally important anions has been a vast growing field in supramolecular chemistry [1,2]. Much research has been devoted to designing sensors that can selectively ...
  • Acid monolayer functionalized iron oxide nanoparticles as catalysts for carbohydrate hydrolysis 

    Ikenberry, Myles; Pena, Leidy; Wei, Daming; Wang, Hongwang; Bossmann, Stefan H.; Wilke, Trenton; Wang, Donghai; Komreddy, Venugopal R.; Rillema, D. Paul; Hohn, Keith L. (Royal Society of Chemistry, 2014-02)
    Superparamagnetic iron oxide nanoparticles were functionalized with a quasi-monolayer of 11-sulfoundecanoic acid and 10-phosphono-1-decanesulfonic acid ligands to create separable solid acid catalysts. The ligands are bound ...
  • Acid-Base and Electrochemical Properties of the MLCT Excited States and One-Electron-Reduced Forms of Ruthenium(II) Complexes Containing 2-(2'-Pyridyl)pyrimidine and 2,2'-Bipyridine in Aqueous Solution 

    Casalboni, Fiorella; Mulazzani, Quinto G.; Clark, Catherine D.; Hoffman, Morton Z.; Orizondo, Peter L.; Perkovic, Marc W.; Rillema, D. Paul (American Chemical Society, 1997-05-21)
    The acid-base and electrochemical properties of the MLCT excited states and the one-electron-reduced forms of the three Ru(bpy)(3)(-)()(p)()(pypm)(p)()(2+) complexes, where bpy = 2,2'-bipyridine, pypm = 2-(2'-pyridyl)pyrimidine, ...
  • Acid-base properties of the ground and excited states of Ruthenium(II) Bis(2,2'-bipyridine) 3-Carboxyl-2,2'-bipyridine 

    Zheng, Greg Y.; Wang, Y.; Rillema, D. Paul (American Chemical Society, 1996-11-20)
    Acid-base properties for ruthenium(II) bis(2,2'-bipyridine) 3-carboxyl-2,2'-bipyridine reveal a ground state pK(a) of 0.82 +/- 0.07 and an excited state pK(a) of 2.31 +/- 0.05, a 1.5 pH unit increase from the ground state. ...
  • Actin-induced dimerization of palladin promotes actin-bundling 

    Vattepu, Ravi; Yadav, Rahu; Beck, Moriah R. (John Wiley & Sons, Inc., 2015-01)
    A subset of actin binding proteins is able to form crosslinks between two or more actin filaments, thus producing structures of parallel or networked bundles. These actin crosslinking proteins interact with actin through ...
  • Addition of H2O and O2 to acetone and dimethylsulfoxide ligated uranyl(V) dioxocations 

    Leavitt, Christopher M.; Bryantsev, Vyacheslav S.; De Jong, Wibe A.; Diallo, Mamadou S.; Goddard, William A.; Groenewold, Gary S.; Van Stipdonk, Michael J. (American Chemical Society, 2009-03-19)
    Gas-phase complexes of the formula [UO2(lig)]+ (lig = acetone (aco) or dimethylsulfoxide (dmso)) were generated by electrospray ionization (ESI) and studied by tandem ion-trap mass spectrometry to determine the general ...
  • Affinity chromatography of glucose dehydrogenase 

    Carper, W. Robert; Groutas, William C.; Coffin, D.B. (Springer, 1988-01-15)
    Porcine liver beta-D-glucose dehydrogenase, a multi-functional protein, has been purified to apparent homogeneity. The enzyme has been separated from the endoplasmic reticulum using Triton X-114 and further purified using ...
  • Aggregation models of potential cyclical trimethylsulfonium dicyanamide ionic liquid clusters 

    Carper, W. Robert; Langenwalter, Kevin; Nooruddin, Naveed S.; Kullman, Michael J.; Gerhard, Dirk; Wasserscheid, Peter (American Chemical Society, 2009-02-19)
    Raman and infrared spectra of trimethylsulfonium dicyanamide [(CH(3))(3)SN(CN)(2)] are reported and accurately reproduced by DFT methods (B3LYP and B3PW91), MP2, and MP3, and to a lesser extent by the RHF method. The ...
  • Amino acid-derived 1,2-benzisothiazolinone derivatives as novel small-molecule antifungal inhibitors: identification of potential genetic targets 

    Alex, Deepu; Gay-Andrieu, Francoise; May, Jared; Thampi, Linta; Dou, Dengfeng; Mooney, Aileen; Groutas, William C.; Calderone, Richard (American Society of Microbiology, 2012-09)
    We have identified four synthetic compounds (DFD-VI-15, BD-I-186, DFD-V-49, and DFD-V-66) from an amino acid-derived 1,2-benzisothiazolinone (BZT) scaffold that have reasonable MIC50 values against a panel of fungal ...
  • Amino acid-derived phthalimide and saccharin derivatives as inhibitors of human leukocyte elastase, cathepsin G, and proteinase 3 

    Groutas, William C.; Chong, Lee S.; Venkataraman, Radhika; Kuang, Rongze; Epp, Jeffrey B.; Houser-Archield, Nadene; Huang, He; Hoidal, John R. (Elsevier, 1996-08-15)
    Amino acid-derived phthalimide and saccharin derivatives have been investigated for their inhibitory activity toward the serine proteinases human leukocyte elastase, cathepsin G, and proteinase 3. The saccharin derivatives ...
  • Anion-complexation-induced stabilization of charge separation 

    D'Souza, Francis; Subbaiyan, Navaneetha K.; Xie, Yongshu; Hill, Jonathan P.; Ariga, Katsuhiko; Ohkubo, Kei; Fukuzumi, Shunichi (American Chemical Society, 2009-11-11)
    A supramolecular oligochromophoric system possessing exclusive binding sites for both a guest electron acceptor and an anionic cofactor species is developed, and anion-binding-induced stabilization of the charge-separated ...
  • Anthrax toxin protective antigenuInsights into molecular switching from prepore to pore 

    Bann, James G. (Cambridge University Press, 2012-01)
    The protective antigen is a key component of the anthrax toxin, as it allows entry of the enzymatic components edema factor and lethal factor into the host cell, through the formation of a membrane spanning pore. This event ...
  • Antifungal activity of a series of 1,2-benzisothiazol-3(2H)-one derivatives 

    Dou, Dengfeng; Alex, Deepu; Du, Bingfan; Tiew, Kok-Chuan; Aravapalli, Sridhar; Mandadapu, Sivakoteswara Rao; Calderone, Richard; Groutas, William C. (Elsevier, 2011-10-01)
    A series of broad-spectrum antifungal agents based on the 1,2-benzisothiazol-3(2H)-one scaffold is reported. Preliminary structure-activity relationship studies have established the importance of the presence of the ...
  • Antifungal drug discovery: the process and outcomes 

    Calderone, Richard; Sun, Nuo; Gay-Andrieu, Francoise; Groutas, William C.; Weerawarna, Pathum M.; Prasad, Sridhar; Alex, Deepu; Li, Dongmei (Future Medicine Ltd, 2014-06)
    New data suggest that the global incidence of several types of fungal diseases have traditionally been under- documented. Of these, mortality caused by invasive fungal infections remains disturbingly high, equal to or ...