Potent inhibition of norovirus by dipeptidyl α-hydroxyphosphonate transition state mimics

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2013-11
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Authors
Mandadapu, Sivakoteswara Rao
Gunnam, Mallikarjuna Reddy
Kankanamalage, Anushka C. Galasiti
Uy, Roxanne Adeline Z.
Alliston, Kevin R.
Lushington, Gerald H.
Kim, Yunjeong
Chang, Kyeong-Ok
Groutas, William C.
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Sivakoteswara Rao Mandadapu, Mallikarjuna Reddy Gunnam, Anushka C. Galasiti Kankanamalage, Roxanne Adeline Z. Uy, Kevin R. Alliston, Gerald H. Lushington, Yunjeong Kim, Kyeong-Ok Chang, William C. Groutas, Potent inhibition of norovirus by dipeptidyl α-hydroxyphosphonate transition state mimics, Bioorganic & Medicinal Chemistry Letters, Volume 23, Issue 21, 1 November 2013, Pages 5941-5944, ISSN 0960-894X, http://dx.doi.org/10.1016/j.bmcl.2013.08.073

Abstract

The design, synthesis, and evaluation of a series of dipeptidyl α-hydroxyphosphonates is reported. The synthesized compounds displayed high anti-norovirus activity in a cell-based replicon system, as well as high enzyme selectivity.

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http://dx.doi.org/10.1016/j.bmcl.2013.08.073
 http://hdl.handle.net/10057/6570
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