Huang, Weijun; Yamamoto, Yasufumi; Li, Yi; Dou, Dengfeng; Alliston, Kevin R.; Hanzlik, Robert P.; Williams, Todd D.; Groutas, William C.
(American Chemical Society, 2008-04-10)
The mechanism of action of a general class of mechanism-based inhibitors of serine proteases, including human neutrophil elastase (HNE), has been elucidated by determining the X-ray crystal structure of an enzyme-inhibitor ...