text

Synthesis and characterization of receptors to bind anionic components of bacterial membranes

SOAR Repository

Show simple item record

dc.contributor.advisor Burns, Dennis H.
dc.contributor.author Jayasinghe, Champika P.
dc.date.accessioned 2012-11-14T22:03:56Z
dc.date.available 2012-11-14T22:03:56Z
dc.date.copyright 2012
dc.date.issued 2012-05
dc.identifier.other d12009
dc.identifier.uri http://hdl.handle.net/10057/5359
dc.description Thesis (Ph.D.)--Wichita State University, College of Liberal Arts and Sciences, Dept. of Chemistry en_US
dc.description.abstract Small molecules that can selectively recognize phospholipids would likely be useful as tools for chemical biology and may have application as pharmaceuticals. Inspired by the phospholipid binding of antimicrobial peptids found in nature, we have begun to develop synthetic receptors for the head group of phosphatidylglycerol. Among neutral receptors, attention is centered to systems containing the urea subunit. This study reports the re-synthesis of bis-phenolic-oxygen–ether-linked macrocycles and their binding studies towards phosphate anion and phosphatidylglycerol anion by means of 1H NMR and Isothermal Titration Calorimetry (ITC) experiments. Control receptor 8 binds to the inorganic H2PO4- anion in 1:1 binding stoichiometry with a moderate to high binding constant while receptor 7 bind s to PG anion with a moderate binding constant in 1:1 binding stoichiometry. Then it describes the synthesis and characterization of pre-organized neutral anion receptors which could contain a linker with four methylene unit between two aromatic rings. This link could be obtained by olefin ring closing metathesis utilizing Grubb’s catalyst. Finally it describes the study to determine the scope and the utilization of single step ureidoalkylation reaction using N-ethoxymethylene-N’-hexylurea 18 on different types of aromatic rings. en_US
dc.format.extent xxi, 167 p. en
dc.language.iso en_US en_US
dc.publisher Wichita State University en_US
dc.rights Copyright Champika P.Jayasinghe, 2012. All rights reserved en
dc.subject.lcsh Electronic dissertations en
dc.title Synthesis and characterization of receptors to bind anionic components of bacterial membranes en_US
dc.type Dissertation

Files in this item

Icon
Name: d12009_Jayasinghe.pdf
Size: 4.667Mb
Format: application/ pdf
Description: Dissertation
View/Open

This item appears in the following Collection(s)

Show simple item record

Search SOAR


Advanced Search

Browse

My Account

Statistics