The effect of intraluminal contact mediated guidance signals on axonal mismatch during peripheral nerve repair

dc.contributor.author	Daly, William T.
dc.contributor.author	Yao, Li
dc.contributor.author	Abu-rub, Mohammad T.
dc.contributor.author	O'Connell, Claire
dc.contributor.author	Zeugolis, Dimitrios I.
dc.contributor.author	Windebank, Anthony J.
dc.contributor.author	Pandit, Abhay S.
dc.date.accessioned	2012-06-28T17:33:59Z
dc.date.available	2012-06-28T17:33:59Z
dc.date.issued	2012-06-24
dc.identifier.citation	Daly, William T.; Yao, Li; Abu-rub, Mohammad T. ; O'Connell, Claire; Zeugolis, Dimitrios I. ; Windebank, Anthony J. & Abhay S., Pandit.2012.The effect of intraluminal contact mediated guidance signals on axonal mismatch during peripheral nerve repair.Biomaterials, Available online 24 June 2012..	en_US
dc.identifier.issn	0142-9612
dc.identifier.issn	1878-5905
dc.identifier.uri	http://hdl.handle.net/10057/5234
dc.identifier.uri	http://dx.doi.org/10.1016/j.biomaterials.2012.06.002
dc.description	Click on the DOI link below to access the article (may not be free).	en_US
dc.description.abstract	The current microsurgical gold standard for repairing long gap nerve injuries is the autograft. Autograft provides a protective environment for repair and a natural internal architecture, which is essential for regeneration. Current clinically approved hollow nerve guidance conduits allow provision of this protective environment; however they fail to provide an essential internal architecture to the regenerating nerve. In the present study both structured and unstructured intraluminal collagen fibres are investigated to assess their ability to enhance conduit mediated nerve repair. This study presents a direct comparison of both structured and unstructured fibres in vivo. The addition of intraluminal guidance structures was shown to significantly decrease axonal dispersion within the conduit and reduced axonal mismatch of distal nerve targets (p < 0.05). The intraluminal fibres were shown to be successfully incorporated into the host regenerative process, acting as a platform for Schwann cell migration and axonal regeneration. Ultimately the fibres were able to provide a platform for nerve regeneration in a long term regeneration study (16 weeks) and facilitated increased guidance of regenerating axons towards their distal nerve targets.	en_US
dc.description.sponsorship	This material is based upon works supported by the Science Foundation Ireland under Grant No. 07/SRC/B1163 and Enterprise Ireland, Proof of Concept (PC/2008/399), co–funded by the European Regional Development Fund and Ireland's EU Structural Funds Programmes 2007–2013.	en_US
dc.language.iso	en_US	en_US
dc.publisher	Elsevier	en_US
dc.relation.ispartofseries	Biomaterials;Available online 24 June 2012
dc.subject	Nerve guidance conduit	en_US
dc.subject	In vivo	en_US
dc.subject	Biomaterials	en_US
dc.subject	Peripheral nerve	en_US
dc.subject	Repair	en_US
dc.subject	Nerve guide	en_US
dc.title	The effect of intraluminal contact mediated guidance signals on axonal mismatch during peripheral nerve repair	en_US
dc.type	Article	en_US
dc.description.version	Peer reviewed
dc.rights.holder	Copyright © 2012, Elsevier