Tolerogenic dendritic cells and rheumatoid arthritis: current status and perspectives

dc.contributor.author	Zhao, Yunpeng
dc.contributor.author	Zhang, Aijun
dc.contributor.author	Du, Hongxia
dc.contributor.author	Guo, Shuya
dc.contributor.author	Ning, Bin
dc.contributor.author	Yang, Shang-You
dc.date.accessioned	2012-04-27T18:38:48Z
dc.date.available	2012-04-27T18:38:48Z
dc.date.issued	2012-04
dc.identifier.citation	Zhao, Yunpeng, Aijun Zhang, Hongxia Du, Shuya Guo, Bin Ning, and Shangyou Yang. 2012. "Tolerogenic dendritic cells and rheumatoid arthritis: current status and perspectives". Rheumatology International. 32 (4): 837-844.	en_US
dc.identifier.issn	0172-8172
dc.identifier.other	WOS: 000302145800001
dc.identifier.uri	http://hdl.handle.net/10057/5088
dc.identifier.uri	http://dx.doi.org/10.1007/s00296-011-2133-2
dc.description	Click on the DOI link below to access the review article (may not be free).	en_US
dc.description.abstract	Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by the influxation of synovia and synovial compartments with immune cells including dendritic cells (DCs). DCs that induce autoimmune tolerance are called tolerogenic DCs (tolDCs). As a promising immunotherapeutic strategy for RA, tolDCs have received increasing attention. In this review, we first introduce the significant role of tolDCs in autoimmune regulation and then describe the manipulation strategies to generate tolDCs; next, we summarize recent progress in the experimental application of tolDCs for RA therapy, and finally we discuss the perspectives of tolerogenic vaccination for the treatment for RA in clinic.	en_US
dc.language.iso	en_US	en_US
dc.publisher	Springer	en_US
dc.relation.ispartofseries	Rheumatology International;2012, v.32, no.4
dc.subject	Rheumatoid arthritis	en_US
dc.subject	Dendritic cells	en_US
dc.subject	Tolerogenic DCs	en_US
dc.subject	Tregs	en_US
dc.subject	Autoimmune	en_US
dc.subject.classification	RHEUMATOLOGY
dc.title	Tolerogenic dendritic cells and rheumatoid arthritis: current status and perspectives	en_US
dc.type	Article	en_US
dc.description.version	Peer reviewed
dc.rights.holder	Copyright by Springer-Verlag 2011