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Tolerogenic dendritic cells and rheumatoid arthritis: current status and perspectives

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dc.contributor.author Zhao, Yunpeng
dc.contributor.author Zhang, Aijun
dc.contributor.author Du, Hongxia
dc.contributor.author Guo, Shuya
dc.contributor.author Ning, Bin
dc.contributor.author Yang, Shang-You
dc.date.accessioned 2012-04-27T18:38:48Z
dc.date.available 2012-04-27T18:38:48Z
dc.date.issued 2012-04
dc.identifier.citation Zhao, Yunpeng, Aijun Zhang, Hongxia Du, Shuya Guo, Bin Ning, and Shangyou Yang. 2012. "Tolerogenic dendritic cells and rheumatoid arthritis: current status and perspectives". Rheumatology International. 32 (4): 837-844. en_US
dc.identifier.issn 0172-8172
dc.identifier.other WOS: 000302145800001
dc.identifier.uri http://hdl.handle.net/10057/5088
dc.identifier.uri http://dx.doi.org/10.1007/s00296-011-2133-2
dc.description Click on the DOI link below to access the review article (may not be free). en_US
dc.description.abstract Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by the influxation of synovia and synovial compartments with immune cells including dendritic cells (DCs). DCs that induce autoimmune tolerance are called tolerogenic DCs (tolDCs). As a promising immunotherapeutic strategy for RA, tolDCs have received increasing attention. In this review, we first introduce the significant role of tolDCs in autoimmune regulation and then describe the manipulation strategies to generate tolDCs; next, we summarize recent progress in the experimental application of tolDCs for RA therapy, and finally we discuss the perspectives of tolerogenic vaccination for the treatment for RA in clinic. en_US
dc.language.iso en_US en_US
dc.publisher Springer en_US
dc.relation.ispartofseries Rheumatology International;2012, v.32, no.4
dc.subject Rheumatoid arthritis en_US
dc.subject Dendritic cells en_US
dc.subject Tolerogenic DCs en_US
dc.subject Tregs en_US
dc.subject Autoimmune en_US
dc.subject.classification RHEUMATOLOGY
dc.title Tolerogenic dendritic cells and rheumatoid arthritis: current status and perspectives en_US
dc.type Article en_US
dc.description.version Peer reviewed
dc.rights.holder Copyright by Springer-Verlag 2011

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