Potent norovirus inhibitors based on the acyclic sulfamide scaffold
Mandadapu, Sivakoteswara Rao
Gunnam, Mallikarjuna Reddy
Alliston, Kevin R.
Groutas, William C.
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Dou, D., K.C. Tiew, S.R. Mandadapu, M.R. Gunnam, K.R. Alliston, Y. Kim, K.O. Chang, and W.C. Groutas. 2012. "Potent norovirus inhibitors based on the acyclic sulfamide scaffold". Bioorganic & Medicinal Chemistry. 20 (6): 2111-2118.
The development of small molecule therapeutics to combat norovirus infection is of considerable interest from a public health perspective because of the highly contagious nature of noroviruses. A series of amino acid-derived acyclic sulfamide-based norovirus inhibitors has been synthesized and evaluated using a cell-based replicon system. Several compounds were found to display potent anti-norovirus activity, low toxicity, and good aqueous solubility. These compounds are suitable for further optimization of pharmacological and ADMET properties.
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