Cytotoxicity of release products from magnetic nanocomposites in targeted drug delivery

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dc.contributor Wichita State University. Department of Mechanical Engineering en_US
dc.contributor.author Wamocha, Humphrey Lusenaka en_US
dc.contributor.author Misak, Heath Edward en_US
dc.contributor.author Song, Z. en_US
dc.contributor.author Chu, H.Y. en_US
dc.contributor.author Chen, Y.Y. en_US
dc.contributor.author Asmatulu, Ramazan en_US
dc.contributor.author Yang, Shang-You en_US
dc.contributor.author Ho, J.C. en_US
dc.date.accessioned 2012-03-30T16:14:39Z
dc.date.available 2012-03-30T16:14:39Z
dc.date.issued 2011-11-09 en_US
dc.identifier 22071353.0 en_US
dc.identifier 8813912 en_US
dc.identifier 0885328211421989 en_US
dc.identifier.citation Journal of biomaterials applications. 2011 Nov 9. [Epub ahead of print] en_US
dc.identifier.issn 1530-8022 en_US
dc.identifier.issn 0885-3282 en_US
dc.identifier.uri http://dx.doi.org/10.1177/0885328211421989 en_US
dc.identifier.uri http://hdl.handle.net/10057/5008
dc.description Click on the DOI link below to access the article (may not be free). en_US
dc.description.abstract The efficacy of chemotherapy can be significantly improved if the therapeutic agent remains localized at the afflicted area and released at controlled rates. Such a targeted drug delivery can be achieved using magnetic nanocomposite (MNC), which incorporates drug and magnetic nanoparticles in biodegradable polymer microspheres. Reported here are results from an in vitro study on drug release rate and cytotoxicity of other release products from MNC. The model system contains an anti-cancer chemotherapy agent 5-flurouracil (5-FU) and (Co(0.5)Zn(0.5))Fe(2)O(4) in poly(lactic-co-glycolic acid) (PLGA) matrix produced by an oil/oil emulsion technique. Cell proliferation data indicate a sustained release of 5-FU for mouse macrophage cell eradication, whereas other microsphere components of magnetic nanoparticles and PLGA have little cytotoxic effects. en_US
dc.language.iso eng en_US
dc.publisher Sage Publications en_US
dc.relation.ispartofseries Journal of Biomaterials Applications en_US
dc.source NLM en_US
dc.title Cytotoxicity of release products from magnetic nanocomposites in targeted drug delivery en_US
dc.type Article en_US
dc.description.version peer reviewed en_US
dc.rights.holder Copyright © The Author(s) 2011 en_US

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