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dc.contributorWichita State University. Department of Mechanical Engineeringen_US
dc.contributor.authorWamocha, Humphrey Lusenakaen_US
dc.contributor.authorMisak, Heath Edwarden_US
dc.contributor.authorSong, Zhengen_US
dc.contributor.authorChu, H.Y.en_US
dc.contributor.authorChen, Y.Y.en_US
dc.contributor.authorAsmatulu, Ramazanen_US
dc.contributor.authorYang, Shang-Youen_US
dc.contributor.authorHo, J. C.en_US
dc.identifier.citationJournal of biomaterials applications. 2011 Nov 9. [Epub ahead of print]en_US
dc.descriptionClick on the DOI link below to access the article (may not be free).en_US
dc.description.abstractThe efficacy of chemotherapy can be significantly improved if the therapeutic agent remains localized at the afflicted area and released at controlled rates. Such a targeted drug delivery can be achieved using magnetic nanocomposite (MNC), which incorporates drug and magnetic nanoparticles in biodegradable polymer microspheres. Reported here are results from an in vitro study on drug release rate and cytotoxicity of other release products from MNC. The model system contains an anti-cancer chemotherapy agent 5-flurouracil (5-FU) and (Co(0.5)Zn(0.5))Fe(2)O(4) in poly(lactic-co-glycolic acid) (PLGA) matrix produced by an oil/oil emulsion technique. Cell proliferation data indicate a sustained release of 5-FU for mouse macrophage cell eradication, whereas other microsphere components of magnetic nanoparticles and PLGA have little cytotoxic effects.en_US
dc.publisherSage Publicationsen_US
dc.relation.ispartofseriesJournal of Biomaterials Applicationsen_US
dc.titleCytotoxicity of release products from magnetic nanocomposites in targeted drug deliveryen_US
dc.description.versionpeer revieweden_US
dc.rights.holderCopyright © The Author(s) 2011en_US

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