Zidovudine adherence among individuals with HIV infection

dc.contributor	Wichita State University. Department of Physician Assistant	en_US
dc.contributor.author	Muma, Richard D.	en_US
dc.contributor.author	Ross, M.W.	en_US
dc.contributor.author	Parcel, G.S.	en_US
dc.contributor.author	Pollard, R.B.	en_US
dc.date.accessioned	2012-03-13T21:58:26Z
dc.date.available	2012-03-13T21:58:26Z
dc.date.issued	1995	en_US
dc.identifier	8547359	en_US
dc.identifier	8915313	en_US
dc.identifier	XM2FB60VM7P443JQ	en_US
dc.identifier.citation	AIDS care. 1995; 7(4): 439-47.	en_US
dc.identifier.issn	0954-0121	en_US
dc.identifier.uri	http://dx.doi.org/10.1080/09540129550126399	en_US
dc.identifier.uri	http://hdl.handle.net/10057/4840
dc.description	Click on the DOI link below to access the article (may not be free).	en_US
dc.description.abstract	The objective was to investigate the relationships among health beliefs, attitudes, and zidovudine compliance in individuals with HIV infection. A survey was administered to 52 individuals with HIV infection. The survey items, which reflected concerns expressed about zidovudine, were generated based on barriers to and benefits of zidovudine and the perceived susceptibility to and perceived severity of HIV as described by the health belief model (HBM). These items were expressed as attitudes and beliefs. Items were subjected to factor analysis, and survey results were correlated with laboratory data to predict adherence to their prescribed medication-taking regimen. Data indicated that 42.3% of the subjects were compliant with zidovudine. Factor analysis identified four dimensions: problems taking and scepticism about zidovudine; degree of concern about HIV; perceived severity of HIV; and physical barriers to taking zidovudine. Logistic regression analysis (forward conditional entry) identified those who were having problems taking zidovudine and who were sceptical about its effectiveness, and ethnicity as significant independent predictors of compliance, correctly classifying 75% of cases (p < 0.01). The fact that subjects who have problems taking zidovudine or are sceptical about the value of zidovudine are less compliant, and that this dimension is a significant predictor of compliance, suggests that non-compliance is related to attitudes and beliefs about zidovudine. This is consistent with the HBM, which holds that the balance between barriers and benefits of a health-related behaviour are significant determinants of outcome.	en_US
dc.format.extent	439-47	en_US
dc.language.iso	eng	en_US
dc.publisher	Association of Schools of Allied Health Professions	en_US
dc.relation.ispartofseries	Aids Care	en_US
dc.relation.ispartofseries	AIDS Care	en_US
dc.source	NLM	en_US
dc.subject.mesh	Adult	en_US
dc.subject.mesh	African Americans	en_US
dc.subject.mesh	Antiviral Agents/therapeutic use	en_US
dc.subject.mesh	Attitude to Health	en_US
dc.subject.mesh	Cross-Sectional Studies	en_US
dc.subject.mesh	Culture	en_US
dc.subject.mesh	Factor Analysis, Statistical	en_US
dc.subject.mesh	Female	en_US
dc.subject.mesh	HIV Infections/drug therapy	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Logistic Models	en_US
dc.subject.mesh	Male	en_US
dc.subject.mesh	Middle Aged	en_US
dc.subject.mesh	Models, Psychological	en_US
dc.subject.mesh	Patient Compliance	en_US
dc.subject.mesh	Reverse Transcriptase Inhibitors/therapeutic use	en_US
dc.subject.mesh	Texas	en_US
dc.subject.mesh	Zidovudine/therapeutic use	en_US
dc.title	Zidovudine adherence among individuals with HIV infection	en_US
dc.type	Article	en_US
dc.coverage.spacial	England	en_US
dc.description.version	Peer reviewed	en_US
dc.rights.holder	Copyright © Association of Schools of Allied Health Professions	en_US

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Richard D. Muma [97]
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