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Effects of neocortical lesions on the P300 component of the auditory evoked response

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dc.contributor Wichita State University. Department of Communication Sciences and Disorders en_US
dc.contributor.author Obert, Allan D. en_US
dc.contributor.author Cranford, Jerry L. en_US
dc.date.accessioned 2012-02-29T18:34:41Z
dc.date.available 2012-02-29T18:34:41Z
dc.date.issued 1990-11 en_US
dc.identifier 2285067 en_US
dc.identifier 7909513 en_US
dc.identifier.citation The American journal of otology. 1990 Nov; 11(6): 447-53. en_US
dc.identifier.issn 0192-9763 en_US
dc.identifier.uri http://ovidsp.tx.ovid.com/sp-3.5.1a/ovidweb.cgi?T=JS&PAGE=fulltext&D=ovft&AN=00000455-199011000-00013&NEWS=N&CSC=Y&CHANNEL=PubMed en_US
dc.identifier.uri http://hdl.handle.net/10057/4693
dc.description Click on the link below to access the article (may not be free). en_US
dc.description.abstract P300 event-related potentials were recorded in 10 subjects with neocortical lesions, and 10 control subjects, using a basic oddball paradigm. In separate tests, subjects discriminated rare and frequent tones that differed with respect to frequency, or discriminated the tones in a noise background. Subjects were required to count the number of rare stimuli that occurred during test runs. Recordings were obtained from vertex (Cz) sites referenced to linked earlobe electrodes. Control subjects exhibited P300s on all test runs. Decreasing stimulus differences relative to frequency, or adding background noise, produced significant increases in P300 latency plus decreases in amplitude. In contrast, two of the 10 lesion subjects failed to demonstrate P300 responses, although both subjects accurately counted the rare stimuli. With the remaining lesion subjects, absent or significantly delayed P300 responses occurred in 53 percent of the test runs, while accurate counts of the rare stimuli were maintained in all test runs. Absent or delayed P300s in the lesion group was not correlated with location or extent of the lesions. These results indicate that, while the P300 is susceptible to neocortical damage, it reflects cognitive processing other than simply discriminating differences between rare and frequent stimuli. en_US
dc.format.extent 447-53 en_US
dc.language.iso eng en_US
dc.publisher Lippincott Williams & Wilkins en_US
dc.relation.ispartofseries The American Journal of Otology en_US
dc.relation.ispartofseries Am J Otol en_US
dc.source NLM en_US
dc.subject.mesh Acoustic Stimulation en_US
dc.subject.mesh Acoustics en_US
dc.subject.mesh Adolescent en_US
dc.subject.mesh Adult en_US
dc.subject.mesh Brain Diseases/physiopathology en_US
dc.subject.mesh Brain Injuries/physiopathology en_US
dc.subject.mesh Cerebral Cortex/physiopathology en_US
dc.subject.mesh Electrophysiology en_US
dc.subject.mesh Evoked Potentials, Auditory/physiology en_US
dc.subject.mesh Female en_US
dc.subject.mesh Humans en_US
dc.subject.mesh Male en_US
dc.subject.mesh Middle Aged en_US
dc.subject.mesh Reaction Time/physiology en_US
dc.title Effects of neocortical lesions on the P300 component of the auditory evoked response en_US
dc.type Article en_US
dc.coverage.spacial United States en_US
dc.description.version peer reviewed en_US
dc.rights.holder Copyright © 1990, The American Journal of Otology en_US

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