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dc.contributorWichita State University. Department of Communication Sciences and Disordersen_US
dc.contributor.authorObert, Allan D.en_US
dc.contributor.authorCranford, Jerry L.en_US
dc.date.accessioned2012-02-29T18:34:41Z
dc.date.available2012-02-29T18:34:41Z
dc.date.issued1990-11en_US
dc.identifier2285067en_US
dc.identifier7909513en_US
dc.identifier.citationThe American journal of otology. 1990 Nov; 11(6): 447-53.en_US
dc.identifier.issn0192-9763en_US
dc.identifier.urihttp://ovidsp.tx.ovid.com/sp-3.5.1a/ovidweb.cgi?T=JS&PAGE=fulltext&D=ovft&AN=00000455-199011000-00013&NEWS=N&CSC=Y&CHANNEL=PubMeden_US
dc.identifier.urihttp://hdl.handle.net/10057/4693
dc.descriptionClick on the link below to access the article (may not be free).en_US
dc.description.abstractP300 event-related potentials were recorded in 10 subjects with neocortical lesions, and 10 control subjects, using a basic oddball paradigm. In separate tests, subjects discriminated rare and frequent tones that differed with respect to frequency, or discriminated the tones in a noise background. Subjects were required to count the number of rare stimuli that occurred during test runs. Recordings were obtained from vertex (Cz) sites referenced to linked earlobe electrodes. Control subjects exhibited P300s on all test runs. Decreasing stimulus differences relative to frequency, or adding background noise, produced significant increases in P300 latency plus decreases in amplitude. In contrast, two of the 10 lesion subjects failed to demonstrate P300 responses, although both subjects accurately counted the rare stimuli. With the remaining lesion subjects, absent or significantly delayed P300 responses occurred in 53 percent of the test runs, while accurate counts of the rare stimuli were maintained in all test runs. Absent or delayed P300s in the lesion group was not correlated with location or extent of the lesions. These results indicate that, while the P300 is susceptible to neocortical damage, it reflects cognitive processing other than simply discriminating differences between rare and frequent stimuli.en_US
dc.format.extent447-53en_US
dc.language.isoengen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofseriesThe American Journal of Otologyen_US
dc.relation.ispartofseriesAm J Otolen_US
dc.sourceNLMen_US
dc.subject.meshAcoustic Stimulationen_US
dc.subject.meshAcousticsen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshBrain Diseases/physiopathologyen_US
dc.subject.meshBrain Injuries/physiopathologyen_US
dc.subject.meshCerebral Cortex/physiopathologyen_US
dc.subject.meshElectrophysiologyen_US
dc.subject.meshEvoked Potentials, Auditory/physiologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshReaction Time/physiologyen_US
dc.titleEffects of neocortical lesions on the P300 component of the auditory evoked responseen_US
dc.typeArticleen_US
dc.coverage.spacialUnited Statesen_US
dc.description.versionpeer revieweden_US
dc.rights.holderCopyright © 1990, The American Journal of Otologyen_US


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