Inhibitors of human neutrophil elastase based on a highly functionalized N-amino-4-imidazolidinone scaffold
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Issue Date
2010-09-01
Embargo End Date
Authors
He, Guijia
Dou, Dengfeng
Wei, Liuqing
Alliston, Kevin R.
Groutas, William C.
Advisor
Citation
European journal of medicinal chemistry. 2010 Sep; 45(9): 4280-7.
Abstract
A series of compounds based on the N-amino-4-imidazolidinone scaffold was synthesized and screened against human neutrophil elastase (HNE). These studies lead to the identification of a selective, low micromolar reversible competitive inhibitor of HNE.
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