| dc.contributor |
Wichita State University. Department of Chemistry |
en_US |
| dc.contributor.author |
Dou, Dengfeng |
en_US |
| dc.contributor.author |
He, Guijia |
en_US |
| dc.contributor.author |
Li, Yi |
en_US |
| dc.contributor.author |
Lai, Zhong |
en_US |
| dc.contributor.author |
Wei, Liuqing |
en_US |
| dc.contributor.author |
Alliston, Kevin R. |
en_US |
| dc.contributor.author |
Lushington, Gerald H. |
en_US |
| dc.contributor.author |
Eichhorn, David M. |
en_US |
| dc.contributor.author |
Groutas, William C. |
en_US |
| dc.date.accessioned |
2012-02-06T17:17:22Z |
|
| dc.date.available |
2012-02-06T17:17:22Z |
|
| dc.date.issued |
2010-02-01 |
en_US |
| dc.identifier |
20061159 |
en_US |
| dc.identifier |
9413298 |
en_US |
| dc.identifier |
S0968-0896(09)01149-3 |
en_US |
| dc.identifier |
HL 57788/ R01 HL057788-08 |
en_US |
| dc.identifier.citation |
Bioorganic & medicinal chemistry. 2010 Feb; 18(3): 1093-102. |
en_US |
| dc.identifier.issn |
1464-3391 |
en_US |
| dc.identifier.issn |
0968-0896 |
en_US |
| dc.identifier.uri |
http://dx.doi.org/10.1016/j.bmc.2009.12.057 |
en_US |
| dc.identifier.uri |
http://hdl.handle.net/10057/4416 |
|
| dc.description |
Click on the DOI link below to access the article (may not be free) |
en_US |
| dc.description.abstract |
The S' subsites of human neutrophil proteinase 3 (Pr 3) were probed by constructing diverse libraries of compounds based on the 1,2,3,5-thiatriazolidin-3-one 1,1-dioxide using combinational and click chemistry methods. The multiple points of diversity embodied in the heterocyclic scaffold render it well-suited to the exploration of the S' subsites of Pr 3. Molecular modeling studies suggest that further exploration of the S' subsites of Pr 3 using the aforementioned heterocyclic scaffold may lead to the identification of highly selective, reversible competitive inhibitors of Pr 3. |
en_US |
| dc.description.sponsorship |
NHLBI NIH HHS/ NHLBI NIH HHS |
en_US |
| dc.format.extent |
1093-102 |
en_US |
| dc.language.iso |
eng |
en_US |
| dc.publisher |
Elsevier |
en_US |
| dc.relation.ispartofseries |
Bioorganic & medicinal chemistry |
en_US |
| dc.relation.ispartofseries |
Bioorg. Med. Chem. |
en_US |
| dc.source |
NLM |
en_US |
| dc.subject |
Research Support, N.I.H., Extramural |
en_US |
| dc.subject.mesh |
Crystallography, X-Ray |
en_US |
| dc.subject.mesh |
Humans |
en_US |
| dc.subject.mesh |
Models, Molecular |
en_US |
| dc.subject.mesh |
Myeloblastin/antagonists & inhibitors |
en_US |
| dc.subject.mesh |
Protein Binding |
en_US |
| dc.subject.mesh |
Serine Proteinase Inhibitors/chemistry* |
en_US |
| dc.subject.mesh |
Triazoles/chemistry |
en_US |
| dc.subject.mesh |
Myeloblastin/chemistry |
en_US |
| dc.subject.mesh |
Myeloblastin/metabolism |
en_US |
| dc.subject.mesh |
Serine Proteinase Inhibitors/pharmacology |
en_US |
| dc.subject.mesh |
Serine Proteinase Inhibitors/pharmacology |
en_US |
| dc.subject.mesh |
Triazoles/pharmacology |
en_US |
| dc.title |
Utilization of the 1,2,3,5-thiatriazolidin-3-one 1,1-dioxide scaffold in the design of potential inhibitors of human neutrophil proteinase 3 |
en_US |
| dc.type |
Article |
en_US |
| dc.coverage.spacial |
England |
en_US |
| dc.description.version |
peer reviewed |
en_US |
| dc.rights.holder |
Copyright © 2010, Elsevier |
en_US |