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dc.contributorWichita State University. Department of Chemistryen_US
dc.contributor.authorDou, Dengfengen_US
dc.contributor.authorHe, Guijiaen_US
dc.contributor.authorLi, Yien_US
dc.contributor.authorLai, Zhongen_US
dc.contributor.authorWei, Liuqingen_US
dc.contributor.authorAlliston, Kevin R.en_US
dc.contributor.authorLushington, Gerald H.en_US
dc.contributor.authorEichhorn, David M.en_US
dc.contributor.authorGroutas, William C.en_US
dc.date.accessioned2012-02-06T17:17:22Z
dc.date.available2012-02-06T17:17:22Z
dc.date.issued2010-02-01en_US
dc.identifier20061159en_US
dc.identifier9413298en_US
dc.identifierS0968-0896(09)01149-3en_US
dc.identifierHL 57788/ R01 HL057788-08en_US
dc.identifier.citationBioorganic & medicinal chemistry. 2010 Feb; 18(3): 1093-102.en_US
dc.identifier.issn1464-3391en_US
dc.identifier.issn0968-0896en_US
dc.identifier.urihttp://dx.doi.org/10.1016/j.bmc.2009.12.057en_US
dc.identifier.urihttp://hdl.handle.net/10057/4416
dc.descriptionClick on the DOI link below to access the article (may not be free)en_US
dc.description.abstractThe S' subsites of human neutrophil proteinase 3 (Pr 3) were probed by constructing diverse libraries of compounds based on the 1,2,3,5-thiatriazolidin-3-one 1,1-dioxide using combinational and click chemistry methods. The multiple points of diversity embodied in the heterocyclic scaffold render it well-suited to the exploration of the S' subsites of Pr 3. Molecular modeling studies suggest that further exploration of the S' subsites of Pr 3 using the aforementioned heterocyclic scaffold may lead to the identification of highly selective, reversible competitive inhibitors of Pr 3.en_US
dc.description.sponsorshipNHLBI NIH HHS/ NHLBI NIH HHSen_US
dc.format.extent1093-102en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.ispartofseriesBioorganic & medicinal chemistryen_US
dc.relation.ispartofseriesBioorg. Med. Chem.en_US
dc.sourceNLMen_US
dc.subjectResearch Support, N.I.H., Extramuralen_US
dc.subject.meshCrystallography, X-Rayen_US
dc.subject.meshHumansen_US
dc.subject.meshModels, Molecularen_US
dc.subject.meshMyeloblastin/antagonists & inhibitorsen_US
dc.subject.meshProtein Bindingen_US
dc.subject.meshSerine Proteinase Inhibitors/chemistry*en_US
dc.subject.meshTriazoles/chemistryen_US
dc.subject.meshMyeloblastin/chemistryen_US
dc.subject.meshMyeloblastin/metabolismen_US
dc.subject.meshSerine Proteinase Inhibitors/pharmacologyen_US
dc.subject.meshSerine Proteinase Inhibitors/pharmacologyen_US
dc.subject.meshTriazoles/pharmacologyen_US
dc.titleUtilization of the 1,2,3,5-thiatriazolidin-3-one 1,1-dioxide scaffold in the design of potential inhibitors of human neutrophil proteinase 3en_US
dc.typeArticleen_US
dc.coverage.spacialEnglanden_US
dc.description.versionpeer revieweden_US
dc.rights.holderCopyright © 2010, Elsevieren_US


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