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dc.contributorWichita State University. Department of Chemistryen_US
dc.contributor.authorGroutas, William C.en_US
dc.contributor.authorStanga, Michael A.en_US
dc.contributor.authorCastrisos, J. C.en_US
dc.contributor.authorSchatz, E. J.en_US
dc.contributor.authorBrubaker, Michael J.en_US
dc.date.accessioned2012-02-06T17:17:16Z
dc.date.available2012-02-06T17:17:16Z
dc.date.issued1990-10-01en_US
dc.identifier2280356.0en_US
dc.identifier2985195Ren_US
dc.identifierHL 38048en_US
dc.identifier.citationJournal of pharmaceutical sciences. 1990 Oct; 79(10): 886-8.en_US
dc.identifier.issn0022-3549en_US
dc.identifier.urihttp://hdl.handle.net/10057/4404
dc.descriptionFull text of this article is not available in SOAR.en_US
dc.description.abstractA series of pyridinium and phenyl carboxylate derivatives of 3-alkyl-N-hydroxysuccinimide has been synthesized; the compounds have been shown to be highly effective, time-dependent inactivators of human leukocyte elastase. The cationic inhibitor having an isobutyl side chain as the P1 residue (3) was found to be the most effective. Human leukocyte cathepsin G and chymotrypsin are also inactivated by these compounds.en_US
dc.description.sponsorshipNHLBI NIH HHSen_US
dc.format.extent886-8en_US
dc.language.isoengen_US
dc.publisherJohn Wiley and Sonsen_US
dc.relation.ispartofseriesJournal of pharmaceutical sciencesen_US
dc.relation.ispartofseriesJ Pharm Scien_US
dc.sourceNLMen_US
dc.subjectIn Vitroen_US
dc.subjectResearch Support, U.S. Gov't, P.H.S.en_US
dc.subject.meshBenzoates/chemical synthesisen_US
dc.subject.meshCathepsin Gen_US
dc.subject.meshCathepsins/antagonists & inhibitorsen_US
dc.subject.meshChemistry, Physicalen_US
dc.subject.meshChymotrypsin/antagonists & inhibitorsen_US
dc.subject.meshHumansen_US
dc.subject.meshLeukocytes/enzymologyen_US
dc.subject.meshMagnetic Resonance Spectroscopyen_US
dc.subject.meshPancreatic Elastase/antagonists & inhibitors*en_US
dc.subject.meshPhysicochemical Phenomenaen_US
dc.subject.meshPyridinium Compounds/chemical synthesisen_US
dc.subject.meshSerine Endopeptidasesen_US
dc.subject.meshSuccinimides/chemical synthesisen_US
dc.subject.meshBenzoates/pharmacologyen_US
dc.subject.meshSuccinimides/pharmacologyen_US
dc.subject.meshPyridinium Compounds/pharmacologyen_US
dc.titleIonic inhibitors of human leukocyte elastase: pyridinium and phenyl carboxylate derivatives of 3-alkyl-N-hydroxysuccinimideen_US
dc.typeArticleen_US
dc.coverage.spacialUnited Statesen_US
dc.description.versionpeer revieweden_US
dc.rights.holderCopyright © 1990 Wiley-Liss, Inc., A Wiley Companyen_US


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