| dc.contributor |
Wichita State University. Department of Chemistry |
en_US |
| dc.contributor.author |
Groutas, William C. |
en_US |
| dc.contributor.author |
Stanga, Michael A. |
en_US |
| dc.contributor.author |
Castrisos, J. C. |
en_US |
| dc.contributor.author |
Schatz, E. J. |
en_US |
| dc.contributor.author |
Brubaker, Michael J. |
en_US |
| dc.date.accessioned |
2012-02-06T17:17:16Z |
|
| dc.date.available |
2012-02-06T17:17:16Z |
|
| dc.date.issued |
1990-10-01 |
en_US |
| dc.identifier |
2280356.0 |
en_US |
| dc.identifier |
2985195R |
en_US |
| dc.identifier |
HL 38048 |
en_US |
| dc.identifier.citation |
Journal of pharmaceutical sciences. 1990 Oct; 79(10): 886-8. |
en_US |
| dc.identifier.issn |
0022-3549 |
en_US |
| dc.identifier.uri |
http://hdl.handle.net/10057/4404 |
|
| dc.description |
Full text of this article is not available in SOAR. |
en_US |
| dc.description.abstract |
A series of pyridinium and phenyl carboxylate derivatives of 3-alkyl-N-hydroxysuccinimide has been synthesized; the compounds have been shown to be highly effective, time-dependent inactivators of human leukocyte elastase. The cationic inhibitor having an isobutyl side chain as the P1 residue (3) was found to be the most effective. Human leukocyte cathepsin G and chymotrypsin are also inactivated by these compounds. |
en_US |
| dc.description.sponsorship |
NHLBI NIH HHS |
en_US |
| dc.format.extent |
886-8 |
en_US |
| dc.language.iso |
eng |
en_US |
| dc.publisher |
John Wiley and Sons |
en_US |
| dc.relation.ispartofseries |
Journal of pharmaceutical sciences |
en_US |
| dc.relation.ispartofseries |
J Pharm Sci |
en_US |
| dc.source |
NLM |
en_US |
| dc.subject |
In Vitro |
en_US |
| dc.subject |
Research Support, U.S. Gov't, P.H.S. |
en_US |
| dc.subject.mesh |
Benzoates/chemical synthesis |
en_US |
| dc.subject.mesh |
Cathepsin G |
en_US |
| dc.subject.mesh |
Cathepsins/antagonists & inhibitors |
en_US |
| dc.subject.mesh |
Chemistry, Physical |
en_US |
| dc.subject.mesh |
Chymotrypsin/antagonists & inhibitors |
en_US |
| dc.subject.mesh |
Humans |
en_US |
| dc.subject.mesh |
Leukocytes/enzymology |
en_US |
| dc.subject.mesh |
Magnetic Resonance Spectroscopy |
en_US |
| dc.subject.mesh |
Pancreatic Elastase/antagonists & inhibitors* |
en_US |
| dc.subject.mesh |
Physicochemical Phenomena |
en_US |
| dc.subject.mesh |
Pyridinium Compounds/chemical synthesis |
en_US |
| dc.subject.mesh |
Serine Endopeptidases |
en_US |
| dc.subject.mesh |
Succinimides/chemical synthesis |
en_US |
| dc.subject.mesh |
Benzoates/pharmacology |
en_US |
| dc.subject.mesh |
Succinimides/pharmacology |
en_US |
| dc.subject.mesh |
Pyridinium Compounds/pharmacology |
en_US |
| dc.title |
Ionic inhibitors of human leukocyte elastase: pyridinium and phenyl carboxylate derivatives of 3-alkyl-N-hydroxysuccinimide |
en_US |
| dc.type |
Article |
en_US |
| dc.coverage.spacial |
United States |
en_US |
| dc.description.version |
peer reviewed |
en_US |
| dc.rights.holder |
Copyright © 1990 Wiley-Liss, Inc., A Wiley Company |
en_US |