Ionic inhibitors of human leukocyte elastase: pyridinium and phenyl carboxylate derivatives of 3-alkyl-N-hydroxysuccinimide

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dc.contributor Wichita State University. Department of Chemistry en_US
dc.contributor.author Groutas, William C. en_US
dc.contributor.author Stanga, Michael A. en_US
dc.contributor.author Castrisos, J. C. en_US
dc.contributor.author Schatz, E. J. en_US
dc.contributor.author Brubaker, Michael J. en_US
dc.date.accessioned 2012-02-06T17:17:16Z
dc.date.available 2012-02-06T17:17:16Z
dc.date.issued 1990-10-01 en_US
dc.identifier 2280356.0 en_US
dc.identifier 2985195R en_US
dc.identifier HL 38048 en_US
dc.identifier.citation Journal of pharmaceutical sciences. 1990 Oct; 79(10): 886-8. en_US
dc.identifier.issn 0022-3549 en_US
dc.identifier.uri http://hdl.handle.net/10057/4404
dc.description Full text of this article is not available in SOAR. en_US
dc.description.abstract A series of pyridinium and phenyl carboxylate derivatives of 3-alkyl-N-hydroxysuccinimide has been synthesized; the compounds have been shown to be highly effective, time-dependent inactivators of human leukocyte elastase. The cationic inhibitor having an isobutyl side chain as the P1 residue (3) was found to be the most effective. Human leukocyte cathepsin G and chymotrypsin are also inactivated by these compounds. en_US
dc.description.sponsorship NHLBI NIH HHS en_US
dc.format.extent 886-8 en_US
dc.language.iso eng en_US
dc.publisher John Wiley and Sons en_US
dc.relation.ispartofseries Journal of pharmaceutical sciences en_US
dc.relation.ispartofseries J Pharm Sci en_US
dc.source NLM en_US
dc.subject In Vitro en_US
dc.subject Research Support, U.S. Gov't, P.H.S. en_US
dc.subject.mesh Benzoates/chemical synthesis en_US
dc.subject.mesh Cathepsin G en_US
dc.subject.mesh Cathepsins/antagonists & inhibitors en_US
dc.subject.mesh Chemistry, Physical en_US
dc.subject.mesh Chymotrypsin/antagonists & inhibitors en_US
dc.subject.mesh Humans en_US
dc.subject.mesh Leukocytes/enzymology en_US
dc.subject.mesh Magnetic Resonance Spectroscopy en_US
dc.subject.mesh Pancreatic Elastase/antagonists & inhibitors* en_US
dc.subject.mesh Physicochemical Phenomena en_US
dc.subject.mesh Pyridinium Compounds/chemical synthesis en_US
dc.subject.mesh Serine Endopeptidases en_US
dc.subject.mesh Succinimides/chemical synthesis en_US
dc.subject.mesh Benzoates/pharmacology en_US
dc.subject.mesh Succinimides/pharmacology en_US
dc.subject.mesh Pyridinium Compounds/pharmacology en_US
dc.title Ionic inhibitors of human leukocyte elastase: pyridinium and phenyl carboxylate derivatives of 3-alkyl-N-hydroxysuccinimide en_US
dc.type Article en_US
dc.coverage.spacial United States en_US
dc.description.version peer reviewed en_US
dc.rights.holder Copyright © 1990 Wiley-Liss, Inc., A Wiley Company en_US

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