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dc.contributorWichita State University. Department of Chemistryen_US
dc.contributor.authorGroutas, William C.en_US
dc.contributor.authorBrubaker, Michael J.en_US
dc.contributor.authorVenkataraman, Radhikaen_US
dc.contributor.authorStanga, Michael A.en_US
dc.date.accessioned2012-02-06T17:17:01Z
dc.date.available2012-02-06T17:17:01Z
dc.date.issued1992-08-15en_US
dc.identifier1637176en_US
dc.identifier0372430en_US
dc.identifier0003-9861(92)90652-Den_US
dc.identifierHL 38048en_US
dc.identifier.citationArchives of biochemistry and biophysics. 1992 Aug 15; 297(1): 144-6.en_US
dc.identifier.issn0003-9861en_US
dc.identifier.urihttp://hdl.handle.net/10057/4381
dc.descriptionFull text of this article is not available in SOAR.en_US
dc.description.abstract(RS)-Diethyl-2-benzyl-succinate was resolved using alpha-chymotrypsin. The two enantiomers were then elaborated to yield (S)-(+) and (R)-(-)-3-benzyl-N-[(methyl-sulfonyl)oxy]succinimide and the inhibitory activity of the two enantiomers toward human leukocyte elastase was subsequently determined. The k2/KI values for the R and S isomers were found to be 330 and 1500 M-1 s-1, respectively.en_US
dc.description.sponsorshipNHLBI NIH HHSen_US
dc.format.extent144-6en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.ispartofseriesArchives of biochemistry and biophysicsen_US
dc.relation.ispartofseriesArch. Biochem. Biophys.en_US
dc.sourceNLMen_US
dc.subjectComparative Studyen_US
dc.subjectResearch Support, U.S. Gov't, P.H.S.en_US
dc.subject.meshChymotrypsinen_US
dc.subject.meshHumansen_US
dc.subject.meshKineticsen_US
dc.subject.meshLeukocyte Elastaseen_US
dc.subject.meshPancreatic Elastase/antagonists & inhibitorsen_US
dc.subject.meshStereoisomerismen_US
dc.subject.meshSuccinimides/chemistryen_US
dc.subject.meshSuccinimides/pharmacologyen_US
dc.titleEnantioselective inhibition of human leukocyte elastaseen_US
dc.typeArticleen_US
dc.coverage.spacialUnited Statesen_US
dc.description.versionpeer revieweden_US
dc.rights.holderCopyright © 1992, Elsevieren_US


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