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Enantioselective inhibition of human leukocyte elastase

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dc.contributor Wichita State University. Department of Chemistry en_US
dc.contributor.author Groutas, William C. en_US
dc.contributor.author Brubaker, Michael J. en_US
dc.contributor.author Venkataraman, Radhika en_US
dc.contributor.author Stanga, Michael A. en_US
dc.date.accessioned 2012-02-06T17:17:01Z
dc.date.available 2012-02-06T17:17:01Z
dc.date.issued 1992-08-15 en_US
dc.identifier 1637176 en_US
dc.identifier 0372430 en_US
dc.identifier 0003-9861(92)90652-D en_US
dc.identifier HL 38048 en_US
dc.identifier.citation Archives of biochemistry and biophysics. 1992 Aug 15; 297(1): 144-6. en_US
dc.identifier.issn 0003-9861 en_US
dc.identifier.uri http://hdl.handle.net/10057/4381
dc.description Full text of this article is not available in SOAR. en_US
dc.description.abstract (RS)-Diethyl-2-benzyl-succinate was resolved using alpha-chymotrypsin. The two enantiomers were then elaborated to yield (S)-(+) and (R)-(-)-3-benzyl-N-[(methyl-sulfonyl)oxy]succinimide and the inhibitory activity of the two enantiomers toward human leukocyte elastase was subsequently determined. The k2/KI values for the R and S isomers were found to be 330 and 1500 M-1 s-1, respectively. en_US
dc.description.sponsorship NHLBI NIH HHS en_US
dc.format.extent 144-6 en_US
dc.language.iso eng en_US
dc.publisher Elsevier en_US
dc.relation.ispartofseries Archives of biochemistry and biophysics en_US
dc.relation.ispartofseries Arch. Biochem. Biophys. en_US
dc.source NLM en_US
dc.subject Comparative Study en_US
dc.subject Research Support, U.S. Gov't, P.H.S. en_US
dc.subject.mesh Chymotrypsin en_US
dc.subject.mesh Humans en_US
dc.subject.mesh Kinetics en_US
dc.subject.mesh Leukocyte Elastase en_US
dc.subject.mesh Pancreatic Elastase/antagonists & inhibitors en_US
dc.subject.mesh Stereoisomerism en_US
dc.subject.mesh Succinimides/chemistry en_US
dc.subject.mesh Succinimides/pharmacology en_US
dc.title Enantioselective inhibition of human leukocyte elastase en_US
dc.type Article en_US
dc.coverage.spacial United States en_US
dc.description.version peer reviewed en_US
dc.rights.holder Copyright © 1992, Elsevier en_US

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