| dc.contributor |
Wichita State University. Department of Chemistry |
en_US |
| dc.contributor.author |
Groutas, William C. |
en_US |
| dc.contributor.author |
Brubaker, Michael J. |
en_US |
| dc.contributor.author |
Venkataraman, Radhika |
en_US |
| dc.contributor.author |
Stanga, Michael A. |
en_US |
| dc.date.accessioned |
2012-02-06T17:17:01Z |
|
| dc.date.available |
2012-02-06T17:17:01Z |
|
| dc.date.issued |
1992-08-15 |
en_US |
| dc.identifier |
1637176 |
en_US |
| dc.identifier |
0372430 |
en_US |
| dc.identifier |
0003-9861(92)90652-D |
en_US |
| dc.identifier |
HL 38048 |
en_US |
| dc.identifier.citation |
Archives of biochemistry and biophysics. 1992 Aug 15; 297(1): 144-6. |
en_US |
| dc.identifier.issn |
0003-9861 |
en_US |
| dc.identifier.uri |
http://hdl.handle.net/10057/4381 |
|
| dc.description |
Full text of this article is not available in SOAR. |
en_US |
| dc.description.abstract |
(RS)-Diethyl-2-benzyl-succinate was resolved using alpha-chymotrypsin. The two enantiomers were then elaborated to yield (S)-(+) and (R)-(-)-3-benzyl-N-[(methyl-sulfonyl)oxy]succinimide and the inhibitory activity of the two enantiomers toward human leukocyte elastase was subsequently determined. The k2/KI values for the R and S isomers were found to be 330 and 1500 M-1 s-1, respectively. |
en_US |
| dc.description.sponsorship |
NHLBI NIH HHS |
en_US |
| dc.format.extent |
144-6 |
en_US |
| dc.language.iso |
eng |
en_US |
| dc.publisher |
Elsevier |
en_US |
| dc.relation.ispartofseries |
Archives of biochemistry and biophysics |
en_US |
| dc.relation.ispartofseries |
Arch. Biochem. Biophys. |
en_US |
| dc.source |
NLM |
en_US |
| dc.subject |
Comparative Study |
en_US |
| dc.subject |
Research Support, U.S. Gov't, P.H.S. |
en_US |
| dc.subject.mesh |
Chymotrypsin |
en_US |
| dc.subject.mesh |
Humans |
en_US |
| dc.subject.mesh |
Kinetics |
en_US |
| dc.subject.mesh |
Leukocyte Elastase |
en_US |
| dc.subject.mesh |
Pancreatic Elastase/antagonists & inhibitors |
en_US |
| dc.subject.mesh |
Stereoisomerism |
en_US |
| dc.subject.mesh |
Succinimides/chemistry |
en_US |
| dc.subject.mesh |
Succinimides/pharmacology |
en_US |
| dc.title |
Enantioselective inhibition of human leukocyte elastase |
en_US |
| dc.type |
Article |
en_US |
| dc.coverage.spacial |
United States |
en_US |
| dc.description.version |
peer reviewed |
en_US |
| dc.rights.holder |
Copyright © 1992, Elsevier |
en_US |