Design, synthesis, and evaluation of inhibitors of Norwalk virus 3C protease

No Thumbnail Available
Issue Date
2011-09-15
Authors
Tiew, Kok-Chuan
He, Guijia
Aravapalli, Sridhar
Mandadapu, Sivakoteswara Rao
Gunnam, Mallikarjuna Reddy
Alliston, Kevin R.
Lushington, Gerald H.
Kim, Yunjeong
Chang, Kyeong-Ok
Groutas, William C.
Advisor
Citation

Bioorganic & medicinal chemistry letters. 2011 Sep 15; 21(18): 5315-9.

Abstract

The first series of peptidyl aldehyde inhibitors that incorporate in their structure a glutamine surrogate has been designed and synthesized based on the known substrate specificity of Norwalk virus 3C protease. The inhibitory activity of the compounds with the protease and with a norovirus cell-based replicon system was investigated. Members of this class of compounds exhibited noteworthy activity both in vitro and in a cell-based replicon system.

Table of Content
Description
Click on the DOI link below to access the article (may not be free).
publication.page.dc.relation.uri
DOI