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Microcapsules through polymer complexation. II. By complex coacervation of polymers containing a low charge density

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dc.contributor Wichita State University. Department of Chemistry en_US
dc.contributor.author Shao, W. en_US
dc.contributor.author Yin, X. N. en_US
dc.contributor.author Stevenson, William T.K. en_US
dc.contributor.author Alexander, Holly en_US
dc.date.accessioned 2012-02-06T17:16:08Z
dc.date.available 2012-02-06T17:16:08Z
dc.date.issued 1991-07-01 en_US
dc.identifier 1892983 en_US
dc.identifier 8100316 en_US
dc.identifier.citation Biomaterials. 1991 Jul; 12(5): 479-88. en_US
dc.identifier.issn 0142-9612 en_US
dc.identifier.uri http://hdl.handle.net/10057/4311
dc.description Full text of this article is not available in SOAR. en_US
dc.description.abstract Relationships between ionizable group content, structure and molecular weight, solubility and solution behaviour, and the efficacy of ionic complex formation through complex coacervation, have been established for a range of sparingly soluble synthetic weak polyelectrolyte polymers with low charge content, based on hydroxyalkyl methacrylates. Selected polymers containing methacrylic acid (acidic) and dimethylaminoethyl methacrylate (basic) functionality show promise as capsule-forming pairs for the entrapment of mammalian cells. The solubility of basic polymers and their ability to form microcapsules with structural integrity is enhanced through quaternization of the N-methyl functionality to the quaternary ammonium group. The survival of guinea-pig erythrocytes encapsulated for 4 d in this promising system was shown by the Drabkin's test to be about 41% of the control sample. en_US
dc.format.extent 479-88 en_US
dc.language.iso eng en_US
dc.publisher Elsevier en_US
dc.relation.ispartofseries Biomaterials en_US
dc.source NLM en_US
dc.subject Research Support, Non-U.S. Gov't en_US
dc.subject.mesh Animals en_US
dc.subject.mesh Biocompatible Materials en_US
dc.subject.mesh Capsules/chemistry en_US
dc.subject.mesh Erythrocyte Aging en_US
dc.subject.mesh Erythrocytes/cytology en_US
dc.subject.mesh Guinea Pigs en_US
dc.subject.mesh Methacrylates/chemistry en_US
dc.subject.mesh Molecular Weight en_US
dc.subject.mesh Osmolar Concentration en_US
dc.subject.mesh Polymers/chemistry en_US
dc.subject.mesh Solubility en_US
dc.title Microcapsules through polymer complexation. II. By complex coacervation of polymers containing a low charge density en_US
dc.type Article en_US
dc.coverage.spacial England en_US
dc.description.version peer reviewed en_US
dc.rights.holder Copyright © 1991, Elsevier en_US

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