Potent inhibition of Norwalk virus by cyclic sulfamide derivatives
Mandadapu, Sivakoteswara Rao
Alliston, Kevin R.
Groutas, William C.
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Bioorganic & medicinal chemistry. 2011 Oct 15; 19(20): 5975-83.
A new class of compounds that exhibit anti-norovirus activity in a cell-based system and embody in their structure a cyclosulfamide scaffold has been identified. The structure of the initial hit (compound 2a, ED(50) 4 µM, TD(50) 50 µM) has been prospected by exploiting multiple points of diversity and generating appropriate structure-activity relationships.
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