Influence of size on apparent scrambling of sequence during CID of b-type ions
Molesworth, Samuel P.
Osburn, Sandra M.
Van Stipdonk, Michael J.
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Journal of the American Society for Mass Spectrometry. 2009 Nov; 20(11): 2174-81.
We investigated the influence of peptide size on the apparent loss of sequence during collision-induced dissociation (CID) of b ions using a group of peptides containing from between 4 and 10 residues. Although scrambling of sequence for b3+ generated from tetrapeptides is minimal, significant formation of nondirect sequence ions (i.e., ions for which scrambling has apparently occurred) was observed for all larger b ions included in the study.
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