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Human chymase inhibitors based on the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold

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Human chymase inhibitors based on the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold

Groutas, William C.; Schechter, Norman M.; He, Shu; Yu, Hongyi; Huang, Peng; Tu, Juan
URI: http://hdl.handle.net/10057/4222
Date: 1999-08-02

Abstract:

A series of compounds that utilize the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold was synthesized and shown to be highly effective inhibitors of recombinant human skin chymase.

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