Human chymase inhibitors based on the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold
Groutas, William C.
Schechter, Norman M.
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Bioorganic & medicinal chemistry letters. 1999 Aug 2; 9(15): 2199-204.
A series of compounds that utilize the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold was synthesized and shown to be highly effective inhibitors of recombinant human skin chymase.
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