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dc.contributor.authorLydy, Michael J.en_US
dc.contributor.authorLasater, J. L.en_US
dc.contributor.authorLandrum, Peter F.en_US
dc.date.accessioned2012-01-24T17:49:42Z
dc.date.available2012-01-24T17:49:42Z
dc.date.issued2000-02en_US
dc.identifier10629277en_US
dc.identifier0357245en_US
dc.identifier.citationArchives of environmental contamination and toxicology. 2000 Feb; 38(2): 163-8.en_US
dc.identifier.issn0090-4341en_US
dc.identifier.urihttp://dx.doi.org/10.1007/s002449910021
dc.identifier.urihttp://hdl.handle.net/10057/4198
dc.description.abstractUptake, biotransformation, and elimination rates for DDE and 2-chlorobiphenyl (2-CB) were examined using fourth instar midge larvae (Chironomus tentans) under a water-only exposure. A two-compartment model that included biotransformation described the kinetics for 2-CB and a one-compartment model was used for DDE. The uptake clearance coefficient (k(u)) was 65.96 +/- 2.09 ml x g(-1) midge x h(-1) for 2-CB and 84.1 +/- 2.7 ml x g(-1) midge x h(-1) for DDE. DDE demonstrated no measurable elimination, while 2-CB showed elimination with faster elimination of parent compound (k(ep) = 0.100 +/- 0.008 h(-1)) compared to the polar metabolites (k(em) = 0.073 +/- 0.016 h(-1)). The biotransformation rate for 2-CB (k(m) = 0.031 +/- 0.005 h(-1)) appeared to be time-dependent with faster rates at the beginning of the accumulation process slowing to a constant once the midge was loaded with chemical. Experimental results indicate a difference in the ability of C. tentans to eliminate 2-CB and its metabolites more quickly than DDE, and these differences were related to the bioconcentration potential of the compounds.en_US
dc.language.isoengen_US
dc.publisherSpringer New Yorken_US
dc.relation.ispartofseriesArchives of environmental contamination and toxicologyen_US
dc.sourceNLMen_US
dc.subjectComparative Studyen_US
dc.subjectResearch Support, Non-U.S. Gov'ten_US
dc.subject.meshAnimalsen_US
dc.subject.meshBiotransformationen_US
dc.subject.meshBiphenyl Compounds/pharmacokineticsen_US
dc.subject.meshChironomidae/drug effectsen_US
dc.subject.meshDichlorodiphenyl Dichloroethylene/pharmacokineticsen_US
dc.subject.meshInsecticides/pharmacokineticsen_US
dc.subject.meshLarva/drug effectsen_US
dc.subject.meshBiphenyl Compounds/toxicityen_US
dc.subject.meshDichlorodiphenyl Dichloroethylene/toxicityen_US
dc.subject.meshInsecticides/toxicityen_US
dc.titleToxicokinetics of DDE and 2-chlorobiphenyl in Chironomus tentansen_US
dc.typeArticleen_US
dc.description.versionpeer revieweden_US
dc.rights.holderCopyright © 2000, Springer New Yorken_US


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