Toxicokinetics of DDE and 2-chlorobiphenyl in Chironomus tentans

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dc.contributor.author Lydy, Michael J. en_US
dc.contributor.author Lasater, J. L. en_US
dc.contributor.author Landrum, Peter F. en_US
dc.date.accessioned 2012-01-24T17:49:42Z
dc.date.available 2012-01-24T17:49:42Z
dc.date.issued 2000-02 en_US
dc.identifier 10629277 en_US
dc.identifier 0357245 en_US
dc.identifier.citation Archives of environmental contamination and toxicology. 2000 Feb; 38(2): 163-8. en_US
dc.identifier.issn 0090-4341 en_US
dc.identifier.uri http://dx.doi.org/10.1007/s002449910021
dc.identifier.uri http://hdl.handle.net/10057/4198
dc.description.abstract Uptake, biotransformation, and elimination rates for DDE and 2-chlorobiphenyl (2-CB) were examined using fourth instar midge larvae (Chironomus tentans) under a water-only exposure. A two-compartment model that included biotransformation described the kinetics for 2-CB and a one-compartment model was used for DDE. The uptake clearance coefficient (k(u)) was 65.96 +/- 2.09 ml x g(-1) midge x h(-1) for 2-CB and 84.1 +/- 2.7 ml x g(-1) midge x h(-1) for DDE. DDE demonstrated no measurable elimination, while 2-CB showed elimination with faster elimination of parent compound (k(ep) = 0.100 +/- 0.008 h(-1)) compared to the polar metabolites (k(em) = 0.073 +/- 0.016 h(-1)). The biotransformation rate for 2-CB (k(m) = 0.031 +/- 0.005 h(-1)) appeared to be time-dependent with faster rates at the beginning of the accumulation process slowing to a constant once the midge was loaded with chemical. Experimental results indicate a difference in the ability of C. tentans to eliminate 2-CB and its metabolites more quickly than DDE, and these differences were related to the bioconcentration potential of the compounds. en_US
dc.language.iso eng en_US
dc.publisher Springer New York en_US
dc.relation.ispartofseries Archives of environmental contamination and toxicology en_US
dc.source NLM en_US
dc.subject Comparative Study en_US
dc.subject Research Support, Non-U.S. Gov't en_US
dc.subject.mesh Animals en_US
dc.subject.mesh Biotransformation en_US
dc.subject.mesh Biphenyl Compounds/pharmacokinetics en_US
dc.subject.mesh Chironomidae/drug effects en_US
dc.subject.mesh Dichlorodiphenyl Dichloroethylene/pharmacokinetics en_US
dc.subject.mesh Insecticides/pharmacokinetics en_US
dc.subject.mesh Larva/drug effects en_US
dc.subject.mesh Biphenyl Compounds/toxicity en_US
dc.subject.mesh Dichlorodiphenyl Dichloroethylene/toxicity en_US
dc.subject.mesh Insecticides/toxicity en_US
dc.title Toxicokinetics of DDE and 2-chlorobiphenyl in Chironomus tentans en_US
dc.type Article en_US
dc.description.version peer reviewed en_US
dc.rights.holder Copyright © 2000, Springer New York en_US

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