| dc.contributor.author |
Lydy, Michael J. |
en_US |
| dc.contributor.author |
Lasater, J. L. |
en_US |
| dc.contributor.author |
Landrum, Peter F. |
en_US |
| dc.date.accessioned |
2012-01-24T17:49:42Z |
|
| dc.date.available |
2012-01-24T17:49:42Z |
|
| dc.date.issued |
2000-02 |
en_US |
| dc.identifier |
10629277 |
en_US |
| dc.identifier |
0357245 |
en_US |
| dc.identifier.citation |
Archives of environmental contamination and toxicology. 2000 Feb; 38(2): 163-8. |
en_US |
| dc.identifier.issn |
0090-4341 |
en_US |
| dc.identifier.uri |
http://dx.doi.org/10.1007/s002449910021 |
|
| dc.identifier.uri |
http://hdl.handle.net/10057/4198 |
|
| dc.description.abstract |
Uptake, biotransformation, and elimination rates for DDE and 2-chlorobiphenyl (2-CB) were examined using fourth instar midge larvae (Chironomus tentans) under a water-only exposure. A two-compartment model that included biotransformation described the kinetics for 2-CB and a one-compartment model was used for DDE. The uptake clearance coefficient (k(u)) was 65.96 +/- 2.09 ml x g(-1) midge x h(-1) for 2-CB and 84.1 +/- 2.7 ml x g(-1) midge x h(-1) for DDE. DDE demonstrated no measurable elimination, while 2-CB showed elimination with faster elimination of parent compound (k(ep) = 0.100 +/- 0.008 h(-1)) compared to the polar metabolites (k(em) = 0.073 +/- 0.016 h(-1)). The biotransformation rate for 2-CB (k(m) = 0.031 +/- 0.005 h(-1)) appeared to be time-dependent with faster rates at the beginning of the accumulation process slowing to a constant once the midge was loaded with chemical. Experimental results indicate a difference in the ability of C. tentans to eliminate 2-CB and its metabolites more quickly than DDE, and these differences were related to the bioconcentration potential of the compounds. |
en_US |
| dc.language.iso |
eng |
en_US |
| dc.publisher |
Springer New York |
en_US |
| dc.relation.ispartofseries |
Archives of environmental contamination and toxicology |
en_US |
| dc.source |
NLM |
en_US |
| dc.subject |
Comparative Study |
en_US |
| dc.subject |
Research Support, Non-U.S. Gov't |
en_US |
| dc.subject.mesh |
Animals |
en_US |
| dc.subject.mesh |
Biotransformation |
en_US |
| dc.subject.mesh |
Biphenyl Compounds/pharmacokinetics |
en_US |
| dc.subject.mesh |
Chironomidae/drug effects |
en_US |
| dc.subject.mesh |
Dichlorodiphenyl Dichloroethylene/pharmacokinetics |
en_US |
| dc.subject.mesh |
Insecticides/pharmacokinetics |
en_US |
| dc.subject.mesh |
Larva/drug effects |
en_US |
| dc.subject.mesh |
Biphenyl Compounds/toxicity |
en_US |
| dc.subject.mesh |
Dichlorodiphenyl Dichloroethylene/toxicity |
en_US |
| dc.subject.mesh |
Insecticides/toxicity |
en_US |
| dc.title |
Toxicokinetics of DDE and 2-chlorobiphenyl in Chironomus tentans |
en_US |
| dc.type |
Article |
en_US |
| dc.description.version |
peer reviewed |
en_US |
| dc.rights.holder |
Copyright © 2000, Springer New York |
en_US |