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dc.contributorWichita State University. Department of Biological Sciences (Loewen, Jonathan J.)
dc.contributor.authorLoewen, Jonathan J.en_US
dc.contributor.authorPeters, Ralph I.en_US
dc.contributor.authorTerrian, David M.en_US
dc.date.accessioned2012-01-24T17:49:34Z
dc.date.available2012-01-24T17:49:34Z
dc.date.issued1992-04-17en_US
dc.identifier1351416en_US
dc.identifier0045503en_US
dc.identifier0006-8993(92)90290-Pen_US
dc.identifier.citationBrain research. 1992 Apr 17; 577(2): 318-20.en_US
dc.identifier.issn0006-8993en_US
dc.identifier.urihttp://dx.doi.org/10.1016/0006-8993(92)90290-P
dc.identifier.urihttp://hdl.handle.net/10057/4182
dc.descriptionClick on the DOI link below to access the article.
dc.description.abstractA rat hippocampal preparation enriched in mossy fiber synaptosomes was employed in an attempt to expose any relationship between endogenous adenosine and the release of dynorphin B-like immunoreactivity (DynB-LI). Presumptive blockade of purinergic receptors increased the spontaneous release of DynB-LI, and reducing synaptic adenosine by exogenous adenosine deaminase increased the K(+)-evoked release. Evoked release of DynB-LI was reduced by inhibitors of adenosine uptake and 5'-nucleotidase. Taken together, these data suggest that adenosine endogenous to hippocampal mossy fiber synaptosomes serves to inhibit the release of one of the peptide neuromodulators of this preparation, and provide support for the concept of autoregulation of release.en_US
dc.language.isoengen_US
dc.publisherElsevier
dc.publisherElsevier BVen_US
dc.relation.ispartofseriesBrain researchen_US
dc.rightsCopyright © 1992, Elsevier
dc.sourceNLMen_US
dc.subjectResearch Support, U.S. Gov't, Non-P.H.S.en_US
dc.subject.mesh5'-Nucleotidase/metabolismen_US
dc.subject.meshAdenosine/physiologyen_US
dc.subject.meshAdenosine Deaminase/metabolismen_US
dc.subject.meshAnimalsen_US
dc.subject.meshDynorphins/analogs & derivativesen_US
dc.subject.meshEndorphins/metabolismen_US
dc.subject.meshHippocampus/metabolismen_US
dc.subject.meshMaleen_US
dc.subject.meshNerve Endings/metabolismen_US
dc.subject.meshNeurotransmitter Agents/physiologyen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Inbred Strainsen_US
dc.subject.meshSynaptosomes/metabolismen_US
dc.subject.meshDynorphins/metabolismen_US
dc.subject.meshHippocampus/ultrastructureen_US
dc.titleAdenosine modulation of dynorphin B release by hippocampal synaptosomesen_US
dc.typeArticleen_US
dc.description.versionPeer reviewed
dc.rights.holderCopyright © 1992, Elsevieren_US


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