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Adenosine modulation of dynorphin B release by hippocampal synaptosomes

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dc.contributor Wichita State University. Department of Biological Sciences (Loewen, Jonathan J.)
dc.contributor.author Loewen, Jonathan J. en_US
dc.contributor.author Peters, Ralph I. en_US
dc.contributor.author Terrian, David M. en_US
dc.date.accessioned 2012-01-24T17:49:34Z
dc.date.available 2012-01-24T17:49:34Z
dc.date.issued 1992-04-17 en_US
dc.identifier 1351416 en_US
dc.identifier 0045503 en_US
dc.identifier 0006-8993(92)90290-P en_US
dc.identifier.citation Brain research. 1992 Apr 17; 577(2): 318-20. en_US
dc.identifier.issn 0006-8993 en_US
dc.identifier.uri http://dx.doi.org/10.1016/0006-8993(92)90290-P
dc.identifier.uri http://hdl.handle.net/10057/4182
dc.description Click on the DOI link below to access the article.
dc.description.abstract A rat hippocampal preparation enriched in mossy fiber synaptosomes was employed in an attempt to expose any relationship between endogenous adenosine and the release of dynorphin B-like immunoreactivity (DynB-LI). Presumptive blockade of purinergic receptors increased the spontaneous release of DynB-LI, and reducing synaptic adenosine by exogenous adenosine deaminase increased the K(+)-evoked release. Evoked release of DynB-LI was reduced by inhibitors of adenosine uptake and 5'-nucleotidase. Taken together, these data suggest that adenosine endogenous to hippocampal mossy fiber synaptosomes serves to inhibit the release of one of the peptide neuromodulators of this preparation, and provide support for the concept of autoregulation of release. en_US
dc.language.iso eng en_US
dc.publisher Elsevier
dc.publisher Elsevier BV en_US
dc.relation.ispartofseries Brain research en_US
dc.rights Copyright © 1992, Elsevier
dc.source NLM en_US
dc.subject Research Support, U.S. Gov't, Non-P.H.S. en_US
dc.subject.mesh 5'-Nucleotidase/metabolism en_US
dc.subject.mesh Adenosine/physiology en_US
dc.subject.mesh Adenosine Deaminase/metabolism en_US
dc.subject.mesh Animals en_US
dc.subject.mesh Dynorphins/analogs & derivatives en_US
dc.subject.mesh Endorphins/metabolism en_US
dc.subject.mesh Hippocampus/metabolism en_US
dc.subject.mesh Male en_US
dc.subject.mesh Nerve Endings/metabolism en_US
dc.subject.mesh Neurotransmitter Agents/physiology en_US
dc.subject.mesh Rats en_US
dc.subject.mesh Rats, Inbred Strains en_US
dc.subject.mesh Synaptosomes/metabolism en_US
dc.subject.mesh Dynorphins/metabolism en_US
dc.subject.mesh Hippocampus/ultrastructure en_US
dc.title Adenosine modulation of dynorphin B release by hippocampal synaptosomes en_US
dc.type Article en_US
dc.description.version Peer reviewed
dc.rights.holder Copyright © 1992, Elsevier en_US

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