Tryptophan and serotonin metabolism after sustained tryptophan infusion

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dc.contributor.author Peters, Ralph I. en_US
dc.contributor.author Buhr, Bruce R. en_US
dc.date.accessioned 2012-01-24T17:49:03Z
dc.date.available 2012-01-24T17:49:03Z
dc.date.issued 1984 en_US
dc.identifier 20488095.0 en_US
dc.identifier 8006959 en_US
dc.identifier 0197-0186(84)90050-0 en_US
dc.identifier.citation Neurochemistry international. 1984; 6(5): 685-91. en_US
dc.identifier.issn 0197-0186 en_US
dc.identifier.uri http://dx.doi.org/10.1016/0197-0186(84)90050-0
dc.identifier.uri http://hdl.handle.net/10057/4152
dc.description Click on the DOI link below to access the article (may not be free). en
dc.description.abstract In an attempt to elucidate the effects of sustained administration of tryptophan on serotonin synthesis and turnover in mammalian brain, mini-osmotic pumps containing tryptophan or vehicle were implanted in albino mice for 24 and 96 h. Despite the extremely low dose of tryptophan administered by these pumps (8-12 mg/kg-day) statistically significant treatment effects were apparent with both treatment durations. Plasma and brain tryptophan concentrations varied in unison, and were inversely related to the tryptophan degradative capabilities of the liver as reflected in tryptophan pyrrolase activity. After 24 h of tryptophan infusion the hepatic enzyme activity was elevated and tryptophan values were no different from controls, and after 96 h the hepatic enzyme activity was reduced and tryptophan values in treated animals were greater than controls. Serotonin was elevated in treated animals after 24 h, but not after 96 h despite the elevated tryptophan concentration at this time. The turnover of serotonin, as evidenced by 5-hydroxyindoleacetic acid concentrations, was not significantly affected by either treatment. Hepatic degradation of tryptophan thus seemed to be an important determinant of total plasma tryptophan, and brain tryptophan values paralleled plasma tryptophan. It appears that serotonin biosynthesis is regulated by factors other than tryptophan availability when the latter is chronically elevated. en_US
dc.language.iso eng en_US
dc.publisher Elsevier en_US
dc.relation.ispartofseries Neurochemistry international en_US
dc.source NLM en_US
dc.title Tryptophan and serotonin metabolism after sustained tryptophan infusion en_US
dc.type Article en_US
dc.description.version peer reviewed en_US
dc.rights.holder Copyright @ 1984 Elsevier

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