Browsing CHEM Faculty Publications by Subject "Catalysis"

Now showing items 1-3 of 3

Evidence for a hydrogen abstraction mechanism in P450-catalyzed N-dealkylations

Bhakta, Mehul N.; Hollenberg, Paul F.; Wimalasena, Kandatege (Royal Society of Chemistry, 2005-01-14)

The experimental evidence presented in this manuscript suggest against the widely accepted single electron/proton transfer mechanism for P450 catalyzed N-dealkylations and provides strong support for a hydrogen atom ...
Microsomal P450-catalyzed N-dealkylation of N,N-dialkylanilines: evidence for a C(alpha)-H abstraction mechanism

Bhakta, Mehul N.; Wimalasena, Kandatege (American Chemical Society, 2002-03-06)

The early proposal that P450-catalyzed N-dealkylation of N,N-dialkylamines proceeds through a single-electron-transfer (SET) mechanism was later challenged in favor of the C(alpha)-H abstraction mechanism. In the present ...
P(450)/NADPH/O(2)- and P(450)/PhIO-catalyzed N-dealkylations are mechanistically distinct

Bhakta, Mehul N.; Hollenberg, Paul F.; Wimalasena, Kandatege (American Chemical Society, 2005-02-09)

A high-valent iron-oxo species analogous to the compound I of peroxidases has been thought to be the activated oxygen species in P450-catalyzed reactions. Spectroscopic characterization of the catalytically competent ...