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Browsing CHEM Faculty Publications by Title

Browsing CHEM Faculty Publications by Title

Now showing items 252-259 of 259

Ultrafast photoinduced energy and electron transfer in multi-modular donor-acceptor conjugates

El-Khouly, Mohamed E.; Wijesinghe, Channa A.; Nesterov, Vladimir N.; Zandler, Melvin E.; Fukuzumi, Shunichi; D'Souza, Francis (Wiley-Blackwell, 2012-10)

New multi-modular donoracceptor conjugates featuring zinc porphyrin (ZnP), catechol-chelated boron dipyrrin (BDP), triphenylamine (TPA) and fullerene (C60), or naphthalenediimide (NDI) have been newly designed and synthesized ...
Ultrafast singlet-singlet energy transfer in self-assembled via metal-ligand axial coordination of free-base porphyrin-zinc phthalocyanine and free-base porphyrin-zinc naphthalocyanine dyads

Maligaspe, Eranda; Kumpulainen, Tatu; Lemmetyinen, Helge; Tkachenko, Nikolai V.; Subbaiyan, Navaneetha K.; Zandler, Melvin E.; D'Souza, Francis (American Chemical Society, 2010-01-14)

Singlet-singlet energy transfer in self-assembled via axial coordination of imidazole-appended (at different positions of one of the meso-phenyl entities) free-base tetraphenylporphyrin, H(2)PIm, to either zinc phthalocyanine, ...
Use of the 1,2,5-thiadiazolidin-3-one 1,1 dioxide and isothiazolidin-3-one 1,1 dioxide scaffolds in the design of potent inhibitors of serine proteinases

Kuang, Rongze; Venkataraman, Radhika; Ruan, Sumei; Groutas, William C. (Elsevier, 1998-03-03)

The attachment of a phosphate leaving group to the 1,2,5-thiadiazolidin-3-one 1,1 dioxide and isothiazolidin-3-one 1,1 dioxide scaffolds was found to yield highly potent, time-dependent inhibitors of human leukocyte elastase ...
Utilization of the 1,2,3,5-thiatriazolidin-3-one 1,1-dioxide scaffold in the design of potential inhibitors of human neutrophil proteinase 3

Dou, Dengfeng; He, Guijia; Li, Yi; Lai, Zhong; Wei, Liuqing; Alliston, Kevin R.; Lushington, Gerald H.; Eichhorn, David M.; Groutas, William C. (Elsevier, 2010-02-01)

The S' subsites of human neutrophil proteinase 3 (Pr 3) were probed by constructing diverse libraries of compounds based on the 1,2,3,5-thiatriazolidin-3-one 1,1-dioxide using combinational and click chemistry methods. The ...
Utilization of the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold in the design of potent inhibitors of serine proteases: SAR studies using carboxylates

Kuang, Rongze; Epp, Jeffrey B.; Ruan, Sumei; Chong, Lee S.; Venkataraman, Radhika; Tu, Juan; He, Shu; Truong, Tien M.; Groutas, William C. (Elsevier, 2000-05-01)

A series of carboxylate derivatives based on the 1,2,5-thiadiazolidin-3-one 1,1 dioxide and isothiazolidin-3-one 1,1 dioxide scaffolds has been synthesized and the inhibitory profile of these compounds toward human leukocyte ...
Vesicular monoamine transporters: structure-function, pharmacology, and medicinal chemistry

Wimalasena, Kandatege; Wimalasena, Kandatege (John Wiley and Sons, 2011-07-01)

Vesicular monoamine transporters (VMAT) are responsible for the uptake of cytosolic monoamines into synaptic vesicles in monoaminergic neurons. Two closely related VMATs with distinct pharmacological properties and tissue ...
Vesicular monoamine transporter substrate/inhibitor activity of MPTP/MPP+ derivatives: a structure-activity study

Wimalasena, D. Shyamali; Perera, Rohan P.; Heyen, Bruce J.; Balasooriya, Inoka S.; Wimalasena, Kandatege (American Chemical Society, 2008-02-28)

The active metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), N-methyl-4-phenylpyridinium (MPP(+)), selectively destroys the dopaminergic neurons and induces the symptoms of Parkinson's disease. Inhibition ...
X-ray snapshot of the mechanism of inactivation of human neutrophil elastase by 1,2,5-thiadiazolidin-3-one 1,1-dioxide derivatives

Huang, Weijun; Yamamoto, Yasufumi; Li, Yi; Dou, Dengfeng; Alliston, Kevin R.; Hanzlik, Robert P.; Williams, Todd D.; Groutas, William C. (American Chemical Society, 2008-04-10)

The mechanism of action of a general class of mechanism-based inhibitors of serine proteases, including human neutrophil elastase (HNE), has been elucidated by determining the X-ray crystal structure of an enzyme-inhibitor ...