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Browsing CHEM Faculty Publications by Issue Date

Browsing CHEM Faculty Publications by Issue Date

Now showing items 21-40 of 253

Continuous spectrophotometric assay for ascorbate oxidase based on a novel chromophoric substrate, 2-aminoascorbic acid

Wimalasena, Kandatege; Dharmasena, Silpadipathialage (Elsevier, 1993-04-01)

Recently, we reported the development of a sensitive continuous spectrophotometric assay for the ascorbate-dependent mammalian enzyme dopamine beta-monooxygenase based on the novel chromophoric electron donor 2-aminoascorbic ...
3-(Alkylthio)-N-hydroxysuccinimide derivatives: potent inhibitors of human leukocyte elastase

Groutas, William C.; Venkataraman, Radhika; Brubaker, Michael J.; Epp, Jeffrey B.; Chong, Lee S.; Stanga, Michael A.; McClenahan, Jerald J.; Tagusagawa, F. (Elsevier, 1993-08-07)

A series of 3-(alkylthio)-N-hydroxysuccinimide derivatives was synthesized and their inhibitory activity towards human leukocyte elastase (HLE) was investigated. The interaction of the compounds having a 3-alkylthioether ...
Mechanism-based inhibitors of serine proteinases based on the Gabriel-Colman rearrangement

Groutas, William C.; Chong, Lee S.; Venkataraman, Radhika; Epp, Jeffrey B.; Kuang, Rongze; Brubaker, Michael J.; Houser-Archield, Nadene; Huang, He; McClenahan, Jerald J. (Elsevier, 1993-08-16)

Neutrophil-derived mediators such as, for example, the serine proteinase elastase, cathepsin G and proteinase 3, play a critical role in inflammatory lung disease. This report describes the design, synthesis and in vitro ...
Dual-action inhibitors of proteolytic enzymes: potential therapeutic agents for cystic fibrosis and related ailments

Groutas, William C.; Huang, He; Venkataraman, Radhika; Houser-Archield, Nadene; Epp, Jeffrey B. (Elsevier, 1993-10-01)
Efficient inhibition of human leukocyte elastase and cathepsin G by saccharin derivatives

Groutas, William C.; Houser-Archield, Nadene; Chong, Lee S.; Venkataraman, Radhika; Epp, Jeffrey B.; Huang, He; McClenahan, Jerald J. (American Chemical Society, 1993-10-15)

A series of saccharin derivatives I has been synthesized and evaluated for their inhibitory activity toward human leukocyte elastase and cathepsin G. Most of the compounds were found to be efficient and time-dependent ...
Novel potential mechanism-based inhibitors of human leukocyte elastase and cathepsin G: derivatives of isothiazolidin-3-one

Groutas, William C.; Chong, Lee S.; Venkataraman, Radhika (Elsevier, 1993-12-15)

A series of heterocyclic compounds designed to function as mechanism-based inhibitors of human leukocyte elastase and cathepsin G has been synthesized and their inhibitory activity was investigated. These isothiazolidin-3-one ...
Substituted 3-oxo-1,2,5-thiadiazolidine 1,1-dioxides: a new class of potential mechanism-based inhibitors of human leukocyte elastase and cathepsin G

Groutas, William C.; Kuang, Rongze; Venkataraman, Radhika (Elsevier, 1994-01-14)

A series of substituted 3-oxo-1,2,5-thiadiazolidine 1,1-dioxides has been synthesized and their in vitro inhibitory activity toward human leukocyte elastase and cathepsin G was investigated. These compounds were found to ...
Derivatives of 3-alkyl-N-hydroxysuccinimide: probing the effect of structure on bioactivity toward human leukocyte elastase

Groutas, William C.; Brubaker, Michael J.; Chong, Lee S.; Epp, Jeffrey B.; Huang, He; Keller, C. E.; McClenahan, Jerry J.; Givens, R. S.; Singh, R.; Zandler, Melvin E. (Harwood Academic Publishers, 1994-02-01)

A structure-activity relationship study was conducted in order to probe the nature of the interaction between some 3-alkyl-N-hydroxysuccinimide derivatives and human leukocyte elastase. The structural features in substituent ...
Ascorbate based novel high affinity alternate reductants and competitive inhibitors of dopamine beta-monooxygenase

Wimalasena, Kandatege; Dharmasena, Silpadipathialage; Wimalasena, D. Shyamali (Elsevier, 1994-04-15)

A series of ascorbate derivatives has been used to examine the specificity and the chemistry of the reduction site of dopamine beta-monooxygenase (D beta M). Replacement of the 6-OH group of ascorbic acid with either bromine ...
Substrate specificity of ascorbate oxidase: unexpected similarity to the reduction site of dopamine beta-monooxygenase

Wimalasena, Kandatege; Dharmasena, Silpadipathialage (Elsevier, 1994-09-30)

A series of ascorbate derivatives has been used to examine the specificity of the reduction site of ascorbate oxidase. Replacement of the 6-OH group of ascorbic acid with either hydrogen or bromine does not alter the ...
Mechanism-based inhibition of human leukocyte elastase and cathepsin G by substituted dihydrouracils

Groutas, William C.; Huang, He; Epp, Jeffrey B.; Venkataraman, Radhika; McClenahan, Jerry J.; Tagusagawa, F. (Elsevier, 1994-11-29)

A series of dihydrouracil derivatives has been synthesized and investigated for their in vitro inhibitory activity toward human leukocyte elastase (HLE) and cathepsin G (Cath G). Alkyl [sulfonyl(oxy)] uracils 1-2 were found ...
The Gabriel-Colman rearrangement in biological systems: design, synthesis and biological evaluation of phthalimide and saccharin derivatives as potential mechanism-based inhibitors of human leukocyte elastase, cathepsin G and proteinase 3

Groutas, William C.; Chong, Lee S.; Venkataraman, Radhika; Epp, Jeffrey B.; Kuang, Rongze; Houser-Archield, Nadene; Hoidal, John R. (Elsevier, 1995-02-01)

The results of a structure-activity relationship study focusing on the interaction of a series of phthalimide and saccharin derivatives with leukocyte elastase, cathepsin G and proteinase 3 are described. The phthalimide ...
Isoxazoline derivatives as potential inhibitors of the proteolytic enzymes human leukocyte elastase, cathepsin G and proteinase 3: a structure-activity relationship study

Groutas, William C.; Venkataraman, Radhika; Chong, Lee S.; Yoder, James E.; Epp, Jeffrey B.; Stanga, Michael A.; Kim, Eun-Hong (Elsevier, 1995-02-01)
Microcapsules through polymer complexation. Part 3: encapsulation and culture of human Burkitt lymphoma cells in vitro

Wen, Shao; Alexander, Holly; Inchikel, Amar; Stevenson, William T.K. (Elsevier, 1995-03-01)

Methacrylic acid (MAA) based polyelectrolytes were complexed with protonated or quaternized dimethylaminoethyl methacrylate (DMAEMA) containing polyelectrolytes to form microcapsules in vitro. Anchorage independent human ...
Design, synthesis and biological evaluation of succinimide derivatives as potential mechanism-based inhibitors of human leukocyte elastase, cathepsin G and proteinase 3

Groutas, William C.; Brubaker, Michael J.; Chong, Lee S.; Venkataraman, Radhika; Huang, He; Epp, Jeffrey B.; Kuang, Rongze; Hoidal, John R. (Elsevier, 1995-04-01)

Structure-activity relationship study and in vitro biochemical studies with human leukocyte elastase, cathepsin G and proteinase 3 were conducted using a series of succinimide derivatives.
The reduction of membrane-bound dopamine beta-monooxygenase in resealed chromaffin granule ghosts. Is intragranular ascorbic acid a mediator for extragranular reducing equivalents?

Wimalasena, Kandatege; Wimalasena, D. Shyamali (American Society for Biochemistry and Molecular Biology, 1995-11-17)

The role of internal and external reductants in the dopamine beta-monooxygenase (D beta M)-catalyzed conversion of dopamine to norepinephrine has been investigated in resealed chromaffin granule ghosts. The rate of ...
A general progress curve method for the kinetic analysis of suicide enzyme inhibitors

Wimalasena, Kandatege; Haines, Donovan C. (Elsevier, 1996-02-15)

The efficiency of suicide inhibitors is expressed in terms of the kinetic parameters KI and kinact and the partition ratio, which are commonly determined by the well-known dilution assay method. Progress curve analysis ...
Amino acid-derived phthalimide and saccharin derivatives as inhibitors of human leukocyte elastase, cathepsin G, and proteinase 3

Groutas, William C.; Chong, Lee S.; Venkataraman, Radhika; Kuang, Rongze; Epp, Jeffrey B.; Houser-Archield, Nadene; Huang, He; Hoidal, John R. (Elsevier, 1996-08-15)

Amino acid-derived phthalimide and saccharin derivatives have been investigated for their inhibitory activity toward the serine proteinases human leukocyte elastase, cathepsin G, and proteinase 3. The saccharin derivatives ...
Design, synthesis, and in vitro inhibitory activity toward human leukocyte elastase, cathepsin G, and proteinase 3 of saccharin-derived sulfones and congeners

Groutas, William C.; Epp, Jeffrey B.; Venkataraman, Radhika; Kuang, Rongze; Truong, Tien M.; McClenahan, Jerry J.; Prakash, Om (Elsevier, 1996-09-01)

The inhibitory activity toward human leukocyte elastase (HLE), cathepsin G (Cat G), and proteinase 3 (PR 3) of a series of saccharin derivatives having a sulfinate leaving group was investigated. The results of this study ...
Spectral and electrochemical investigations on the "tail-on" and "tail-off" mechanism in pyridine covalently bound zinc(II) porphyrins

D'Souza, Francis; Hsieh, Yi-Ying; Deviprasad, Gollapalli R. (American Chemical Society, 1996-09-11)