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Browsing CHEM Faculty Publications by Title

Browsing CHEM Faculty Publications by Title

Now showing items 39-58 of 253

Controlling the role of oxygen in single molecule fluorescence measurements

English, Douglas S.; Campos, Luis A.; Wang, Zifan; Liu, Jianwei; Wang, Xiang; Ramanathan, Ravishankar; Munoz, Victor (American Chemical Society, 2011-08-28)
Control over photoinduced energy and electron transfer in supramolecular polyads of covalently linked azaBODIPY-bisporphyrin ‘molecular clip’ hosting fullerene

D'Souza, Francis; Amin, Anu N.; El-Khouly, Mohamed E.; Subbaiyan, Navaneetha K.; Zandler, Melvin E.; Fukuzumi, Shunichi (American Chemical Society, 2012-01)

A 'molecular clip' featuring a near-IR emitting fluorophore, BF(2)-chelated tetraarylazadipyrromethane (aza-BODIPY) covalently linked to two porphyrins (MP, M = 2H or Zn) has been newly synthesized to host a three-dimensional ...
A convenient entry to C2- and C3-substituted gulono-gamma-lactone derivatives from L-ascorbic acid

Olabisi, Ayodele O.; Mahindaratne, Mathew P. D.; Wimalasena, Kandatege (American Chemical Society, 2005-08-19)

A convenient method to obtain unknown chiral C2- and C3-functionalized aldono-1,4-lactone derivatives starting from l-ascorbic acid, which would be valuable in the synthesis of derivatives of various pharmacologically ...
A convenient, one-step synthesis of benzyl (Ar) ureas of the type ArCH(2)NHCONHR from Ar and R(1)OCH(2)NHCONHR via ureidoalkylation

Meece, Frederick A.; Jayasinghe, Champika; Histand, Gary; Burns, Dennis H. (American Chemical Society, 2009-04-17)

A method for the one-step C-ureidoalkylation of phenol, anisole, or aniline rings furnishing ArCH(2)NHCONHR (Ar = benzyl) products in moderate to good yields is described. With phenol ring systems, higher yields were ...
Copper ions disrupt dopamine metabolism via inhibition of V-H+-ATPase: a possible contributing factor to neurotoxicity

Wimalasena, D. Shyamali; Wiese, Thomas J.; Wimalasena, Kandatege (John Wiley and Sons, 2007-04-01)

The involvement of copper in the pathophysiology of neurodegeneration has been well documented but is not fully understood. Commonly, the effects are attributed to increased reactive oxygen species (ROS) production due to ...
Corrole-fullerene dyads: formation of long-lived charge-separated states in nonpolar solvents

D'Souza, Francis; Chitta, Raghu; Ohkubo, Kei; Tasior, Mariusz; Subbaiyan, Navaneetha K.; Zandler, Melvin E.; Rogacki, Maciek K.; Gryko, Daniel T.; Fukuzumi, Shunichi (American Chemical Society, 2008-10-29)

The first example of covalently linked free-base corrole-fullerene dyads is reported. In the newly synthesized dyads, the free-energy calculations performed by employing the redox and singlet excited-state energy in both ...
Cyanoscorpionates: synthesis and crystallographic characterization of one-dimensional Cu(I) coordination polymers

Zhao, Ningfeng; Bullinger, John C.; Van Stipdonk, Michael J.; Stern, Charlotte L.; Eichhorn, David M. (American Chemical Society, 2008-07-07)

A new cyanoscorpionate ligand, hydrotris(3- t-butyl-4-cyanopyrazolyl)borate (Tp ( t-Bu,4CN )) is reported. Both Tp ( t-Bu,4CN ) and hydrotris(4-cyano-3-phenylpyrazolyl)borate (Tp (Ph,4CN)) form one-dimensional coordination ...
Cyclosulfamide-based derivatives as inhibitors of noroviruses

Dou, Dengfeng; Mandadapu, Sivakoteswara Rao; Alliston, Kevin R.; Kim, Yunjeong; Chang, Kyeong-Ok; Groutas, William C. (Elsevier, 2011-10-20)

An optimization campaign focused on improving pharmacological activity and physicochemical properties of a recently-identified class of cyclosulfamide-based norovirus inhibitors has been carried out. Dimeric compound 4 was ...
Density functional theory calculations of selected Ru(II) two ring diimine complex dications

Stoyanov, Stanislav R.; Villegas, John M.; Rillema, D. Paul (American Chemical Society, 2002-06-03)

Geometry optimization for a series of ten, two-ring diimine Ru(II) complexes was effected using the Gaussian 98 protocol at density functional theory (DFT) B3LYP level with basis sets 3-21G*and 3-21G**. HOMO-LUMO energy ...
Derivatives of 3-alkyl-N-hydroxysuccinimide: probing the effect of structure on bioactivity toward human leukocyte elastase

Groutas, William C.; Brubaker, Michael J.; Chong, Lee S.; Epp, Jeffrey B.; Huang, He; Keller, C. E.; McClenahan, Jerry J.; Givens, R. S.; Singh, R.; Zandler, Melvin E. (Harwood Academic Publishers, 1994-02-01)

A structure-activity relationship study was conducted in order to probe the nature of the interaction between some 3-alkyl-N-hydroxysuccinimide derivatives and human leukocyte elastase. The structural features in substituent ...
Design and studies on supramolecular ferrocene-porphyrin-fullerene constructs for generating long-lived charge separated states

D'Souza, Francis; Chitta, Raghu; Gadde, Suresh; Islam, D-M Shafiqul; Schumacher, Amy Lea; Zandler, Melvin E.; Araki, Yasuyaki; Ito, Osamu (American Chemical Society, 2006-12-21)

Supramolecular ferrocene-porphyrin-fullerene constructs, in which covalently linked ferrocene-porphyrin-crown ether compounds were self-assembled with alkylammonium cation functionalized fullerenes, have been designed to ...
Design and synthesis of inhibitors of noroviruses by scaffold hopping

Dou, Dengfeng; Mandadapu, Sivakoteswara Rao; Alliston, Kevin R.; Kim, Yunjeong; Chang, Kyeong-Ok; Groutas, William C. (Elsevier, 2011-10-01)

A scaffold hopping strategy was employed to identify new chemotypes that inhibit noroviruses. The replacement of the cyclosulfamide scaffold by an array of heterocyclic scaffolds lead to the identification of additional ...
Design, syntheses, and studies of supramolecular porphyrin-fullerene conjugates, using bis-18-crown-6 appended porphyrins and pyridine or alkyl ammonium functionalized fullerenes

D'Souza, Francis; Chitta, Raghu; Gadde, Suresh; McCarty, Amy L.; Karr, Paul A.; Zandler, Melvin E.; Sandanayaka, Atula S. D.; Araki, Yasuyaki; Ito, Osamu (American Chemical Society, 2006-03-30)

Photoinduced electron-transfer processes in cis and trans functionalized bis-18-crown-6 porphyrin self-assembled with fullerene functionalized with pyridine or alkylammonium cation entities are reported. The structural ...
Design, synthesis and biological evaluation of succinimide derivatives as potential mechanism-based inhibitors of human leukocyte elastase, cathepsin G and proteinase 3

Groutas, William C.; Brubaker, Michael J.; Chong, Lee S.; Venkataraman, Radhika; Huang, He; Epp, Jeffrey B.; Kuang, Rongze; Hoidal, John R. (Elsevier, 1995-04-01)

Structure-activity relationship study and in vitro biochemical studies with human leukocyte elastase, cathepsin G and proteinase 3 were conducted using a series of succinimide derivatives.
Design, synthesis and characterization of novel 1,2-benzisothiazol-3(2H)-one and 1,3,4-oxadiazole hybrid derivatives: Potent inhibitors of Dengue and West Nile virus NS2B/NS3 proteases

Lai, Huiguo; Dou, Dengfeng; Aravapalli, Sridhar; Teramoto, Tadahisa; Lushington, Gerald H.; Mwania, Tom M.; Alliston, Kevin R.; Eichhorn, David M.; Padmanabhan, Radhakrishnan; Groutas, William C. (PERGAMON-ELSEVIER SCIENCE LTD, 2013-01)

1,2-Benzisothiazol-3(2H)-ones and 1,3,4-oxadiazoles individually have recently attracted considerable interest in drug discovery, including as antibacterial and antifungal agents. In this study, a series of functionalized ...
Design, synthesis and characterization of novel 1,2-benzisothiazol-3(2H)-one and 1,3,4-oxadiazole hybrid derivatives: Potent inhibitors of Dengue and West Nile virus NS2B/NS3 proteases

Lai, Huiguo; Dou, Dengfeng; Aravapalli, Sridhar; Teramoto, Tadahisa; Lushington, Gerald H.; Mwania, Tom M.; Alliston, Kevin R.; Eichhorn, David M.; Padmanabhan, Radhakrishnan; Groutas, William C. (Elsevier, 2013-01)

1,2-Benzisothiazol-3(2H)-ones and 1,3,4-oxadiazoles individually have recently attracted considerable interest in drug discovery, including as antibacterial and antifungal agents. In this study, a series of functionalized ...
Design, synthesis, and evaluation of inhibitors of Norwalk virus 3C protease

Tiew, Kok-Chuan; He, Guijia; Aravapalli, Sridhar; Mandadapu, Sivakoteswara Rao; Gunnam, Mallikarjuna Reddy; Alliston, Kevin R.; Lushington, Gerald H.; Kim, Yunjeong; Chang, Kyeong-Ok; Groutas, William C. (Elsevier, 2011-09-15)

The first series of peptidyl aldehyde inhibitors that incorporate in their structure a glutamine surrogate has been designed and synthesized based on the known substrate specificity of Norwalk virus 3C protease. The ...
Design, synthesis, and in vitro evaluation of inhibitors of human leukocyte elastase based on a functionalized cyclic sulfamide scaffold

Zhong, Jiaying; Gan, Xiangdong; Alliston, Kevin R.; Groutas, William C. (Elsevier, 2004-02-01)

The design of novel functionalized templates capable of binding to the active site of serine proteases could potentially lead to the development of potent and highly selective non-covalent inhibitors of these enzymes. Using ...
Design, synthesis, and in vitro evaluation of potential West Nile virus protease inhibitors based on the 1-oxo-1,2,3,4-tetrahydroisoquinoline and 1-oxo-1,2-dihydroisoquinoline scaffolds

Dou, Dengfeng; Viwanathan, Prasanth; Li, Yi; He, Guijia; Alliston, Kevin R.; Lushington, Gerald H.; Brown-Clay, Joshua D.; Padmanabhan, R.; Groutas, William C. (American Chemical Society, 2010-11-08)

The 1-oxo-1, 2, 3, 4-tetrahydroisoquinoline and 1-Oxo-1, 2-dihydroisoquinoline scaffolds were utilized in the design and solution phase synthesis of focused libraries of compounds for screening against West Nile Virus (WNV) ...
Design, synthesis, and in vitro inhibitory activity toward human leukocyte elastase, cathepsin G, and proteinase 3 of saccharin-derived sulfones and congeners

Groutas, William C.; Epp, Jeffrey B.; Venkataraman, Radhika; Kuang, Rongze; Truong, Tien M.; McClenahan, Jerry J.; Prakash, Om (Elsevier, 1996-09-01)

The inhibitory activity toward human leukocyte elastase (HLE), cathepsin G (Cat G), and proteinase 3 (PR 3) of a series of saccharin derivatives having a sulfinate leaving group was investigated. The results of this study ...