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dc.contributor.authorAgiovlasitis, Stamatis
dc.contributor.authorBaynard, Tracy
dc.contributor.authorPitetti, Kenneth H.
dc.contributor.authorFernhall, Bo
dc.date.accessioned2011-12-01T21:17:48Z
dc.date.available2011-12-01T21:17:48Z
dc.date.issued2011-11
dc.date.issued2011en_US
dc.identifier.citationAgiovlasitis, S., T. Baynard, K.H. Pitetti, and B. Fernhall. 2011. "Heart rate complexity in response to upright tilt in persons with Down syndrome". Research in Developmental Disabilities, 32(6), pp:2102-2107en_US
dc.identifier.issn0891-4222
dc.identifier.otherWOS ID:000296304000010
dc.identifier.urihttp://hdl.handle.net/10057/4006
dc.identifier.urihttp://dx.doi.org/ 10.1016/j.ridd.2011.08.015
dc.descriptionClick on the DOI link to access the article (may not be free)en_US
dc.description.abstractPeople with Down syndrome (DS) show altered autonomic response to sympathoexcitation. Cardiac autonomic modulation may be examined with heart rate (HR) complexity which is associated uniquely with cardiovascular risk. This study examined whether the response of HR complexity to passive upright tilt differs between persons with and without DS and whether potential between-group differences in this response are accounted for by differences in body mass index (BMI). The electrocardiogram of 16 persons with DS (8 women, 8 men) and 16 persons without DS (8 women, 8 men) was recorded during 10 min of supine rest and 10 min of upright tilt. For each participant, 550 continuous, steady state, and ectopy-free R-R intervals under each condition were analyzed. Dependent variables were approximate entropy, correlation dimension, StatAv, and the mean R-R interval. In response to tilt, changes in approximate entropy and correlation dimension were reduced in participants with DS (p < 0.0 5). These differences were explained by higher BMI in participants with DS. StatAv increased in persons with DS (p < 0.05) and stayed the same in those without DS even when controlling for BMI. The response of R-R interval did not differ between groups. None of the variables differed between groups at rest. Therefore, people with DS show smaller decrease in HR complexity in response to upright tilt than people without DS partially due to their higher BMI. Resting HR complexity does not differ between persons with and without DS. These results may have implications for cardiovascular risk in people with DS.en_US
dc.language.isoen_USen_US
dc.publisherElsevier Science Ltden_US
dc.relation.ispartofseriesResearch in Developmental Disabilities;32(6), pp:2102-2107.
dc.subjectAutonomic functionen_US
dc.subjectComplexityen_US
dc.subjectDown syndromeen_US
dc.subjectHeart rateen_US
dc.subjectUpright tilten_US
dc.titleHeart rate complexity in response to upright tilt in persons with Down syndromeen_US
dc.typeArticleen_US
dc.description.versionPeer reviewed article
dc.rights.holder© 2011 Elsevier Ltd


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