Heart rate complexity in response to upright tilt in persons with Down syndrome

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dc.contributor.author Agiovlasitis, Stamatis
dc.contributor.author Baynard, Tracy
dc.contributor.author Pitetti, Kenneth H.
dc.contributor.author Fernhall, Bo
dc.date.accessioned 2011-12-01T21:17:48Z
dc.date.available 2011-12-01T21:17:48Z
dc.date.issued 2011-11
dc.date.issued 2011 en_US
dc.identifier.citation Agiovlasitis, S., T. Baynard, K.H. Pitetti, and B. Fernhall. 2011. "Heart rate complexity in response to upright tilt in persons with Down syndrome". Research in Developmental Disabilities, 32(6), pp:2102-2107 en_US
dc.identifier.issn 0891-4222
dc.identifier.other WOS ID:000296304000010
dc.identifier.uri http://hdl.handle.net/10057/4006
dc.identifier.uri http://dx.doi.org/ 10.1016/j.ridd.2011.08.015
dc.description Click on the DOI link to access the article (may not be free) en_US
dc.description.abstract People with Down syndrome (DS) show altered autonomic response to sympathoexcitation. Cardiac autonomic modulation may be examined with heart rate (HR) complexity which is associated uniquely with cardiovascular risk. This study examined whether the response of HR complexity to passive upright tilt differs between persons with and without DS and whether potential between-group differences in this response are accounted for by differences in body mass index (BMI). The electrocardiogram of 16 persons with DS (8 women, 8 men) and 16 persons without DS (8 women, 8 men) was recorded during 10 min of supine rest and 10 min of upright tilt. For each participant, 550 continuous, steady state, and ectopy-free R-R intervals under each condition were analyzed. Dependent variables were approximate entropy, correlation dimension, StatAv, and the mean R-R interval. In response to tilt, changes in approximate entropy and correlation dimension were reduced in participants with DS (p < 0.0 5). These differences were explained by higher BMI in participants with DS. StatAv increased in persons with DS (p < 0.05) and stayed the same in those without DS even when controlling for BMI. The response of R-R interval did not differ between groups. None of the variables differed between groups at rest. Therefore, people with DS show smaller decrease in HR complexity in response to upright tilt than people without DS partially due to their higher BMI. Resting HR complexity does not differ between persons with and without DS. These results may have implications for cardiovascular risk in people with DS. en_US
dc.language.iso en_US en_US
dc.publisher Elsevier Science Ltd en_US
dc.relation.ispartofseries Research in Developmental Disabilities;32(6), pp:2102-2107.
dc.subject Autonomic function en_US
dc.subject Complexity en_US
dc.subject Down syndrome en_US
dc.subject Heart rate en_US
dc.subject Upright tilt en_US
dc.title Heart rate complexity in response to upright tilt in persons with Down syndrome en_US
dc.type Article en_US
dc.description.version Peer reviewed article
dc.rights.holder © 2011 Elsevier Ltd

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