Synthesis and secretion of gonadotropins including structure-function correlates

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dc.contributor.author Bousfield, George R.
dc.contributor.author Dias, James A.
dc.date.accessioned 2011-12-01T17:17:32Z
dc.date.available 2011-12-01T17:17:32Z
dc.date.issued 2011-07-08
dc.identifier PubMed ID:21739108
dc.identifier.citation Bousfield, George R., and James A. Dias. 2011. "Synthesis and secretion of gonadotropins including structure-function correlates". Reviews in Endocrine & Metabolic Disorders, 12(4), pp:289-302. en_US
dc.identifier.issn 1389-9155
dc.identifier.other WOS ID:000296638300004
dc.identifier.uri http://hdl.handle.net/10057/3999
dc.identifier.uri http://dx.doi.org/ 10.1007/s11154-011-9191-3
dc.description Open Access article
dc.description.abstract The synthesis and secretion of the gonadotropic hormones involves coordination of signal transduction, gene expression, protein translation, post-translational folding and modification and finally secretion. The production of biologically active gonadotropin thus requires appropriately folded and glycosylated subunits that assemble to form the heterodimeric hormone. Here we overview recent literature on regulation of gonadotropin subunit gene expression and current understanding of the assembly and secretion of biologically active gonadotropic hormones. Finally, we discuss the therapeutic potential of understanding glycosylation function towards designing new forms of gonadotropins based on observations of physiologically relevant parameters such as age related glycosylation changes. en_US
dc.language.iso en_US en_US
dc.publisher Springer Open Choice en_US
dc.relation.ispartofseries Reviews in Endocrine & Metabolic Disorders;12(4), pp:289-302.
dc.subject Transcription en_US
dc.subject FSH beta en_US
dc.subject LH beta en_US
dc.subject Common alpha subunit en_US
dc.subject GnRH en_US
dc.title Synthesis and secretion of gonadotropins including structure-function correlates en_US
dc.type Article en_US
dc.description.version Peer reviewed article
dc.rights.holder ©The Author(s) 2011

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