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dc.contributor.authorBousfield, George R.
dc.contributor.authorDias, James A.
dc.date.accessioned2011-12-01T17:17:32Z
dc.date.available2011-12-01T17:17:32Z
dc.date.issued2011-07-08
dc.identifierPubMed ID:21739108
dc.identifier.citationBousfield, George R., and James A. Dias. 2011. "Synthesis and secretion of gonadotropins including structure-function correlates". Reviews in Endocrine & Metabolic Disorders, 12(4), pp:289-302.en_US
dc.identifier.issn1389-9155
dc.identifier.otherWOS ID:000296638300004
dc.identifier.urihttp://hdl.handle.net/10057/3999
dc.identifier.urihttp://dx.doi.org/ 10.1007/s11154-011-9191-3
dc.descriptionOpen Access article
dc.description.abstractThe synthesis and secretion of the gonadotropic hormones involves coordination of signal transduction, gene expression, protein translation, post-translational folding and modification and finally secretion. The production of biologically active gonadotropin thus requires appropriately folded and glycosylated subunits that assemble to form the heterodimeric hormone. Here we overview recent literature on regulation of gonadotropin subunit gene expression and current understanding of the assembly and secretion of biologically active gonadotropic hormones. Finally, we discuss the therapeutic potential of understanding glycosylation function towards designing new forms of gonadotropins based on observations of physiologically relevant parameters such as age related glycosylation changes.en_US
dc.language.isoen_USen_US
dc.publisherSpringer Open Choiceen_US
dc.relation.ispartofseriesReviews in Endocrine & Metabolic Disorders;12(4), pp:289-302.
dc.subjectTranscriptionen_US
dc.subjectFSH betaen_US
dc.subjectLH betaen_US
dc.subjectCommon alpha subuniten_US
dc.subjectGnRHen_US
dc.titleSynthesis and secretion of gonadotropins including structure-function correlatesen_US
dc.typeArticleen_US
dc.description.versionPeer reviewed article
dc.rights.holder©The Author(s) 2011


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