Show simple item record

dc.contributor.advisorD'Souza, Francis
dc.contributor.authorAmin, Anu N.
dc.contributor.authorMaligaspe, Eranda
dc.date.accessioned2010-09-23T14:43:33Z
dc.date.available2010-09-23T14:43:33Z
dc.date.issued2010-04-23
dc.identifier.citationAmin, Anu N. and Eranda Maligaspe (2010). Synthesis of asymmetrically substituted push-pull phthalocyanines as potential photodynamic therapy agent. -- In Proceedings: 6th Annual Symposium: Graduate Research and Scholarly Projects. Wichita, KS: Wichita State University, p. 67-68en
dc.identifier.urihttp://hdl.handle.net/10057/3182
dc.descriptionPaper presented to the 6th Annual Symposium on Graduate Research and Scholarly Projects (GRASP) held at the Hughes Metropolitan Complex, Wichita State University, April 23, 2010.en
dc.descriptionResearch completed at the Department of Chemistry, College of Liberal Arts and Sciencesen
dc.description.abstractOver the past decade, photodynamic therapy (PDT) has begun to gain worldwide attention either as a primary or as an alternate treatment for solid cancers.1The success of the treatment largely depends upon the tumor-selectivity and photosensitizing properties of the photosensitizer used. Phthalocyanines with absorption extending well into the near-IR region have been considered to be potential PDT agents. In the present study, the synthesis of asymmetrically substituted phthalocyanine has been described. In order to avoid the tedious separation of a mixture of phthalocyanines prepared by statistical method, Kobayashi’s ring expansion of boron subphthalocyanine route2 has been used. This route produces exclusively 3:1 asymmetrical phthalocyanine. Fluorinated boron subphthalocyanine and diiminoisoindoline of glycol chain substituted phthalonitrile were used as reagents. Mild reaction conditions were employed using dimethylaminoethanol as the solvent. The compound has been characterized by optical absorption and emission (steady-state and time-resolved), ¹H and ¹⁹F NMR, and mass spectroscopic analysis. Studies on singlet oxygen yield and other studies are in progress.en
dc.format.extent147454 bytes
dc.format.extent1843 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_USen
dc.publisherWichita State University. Graduate Schoolen
dc.relation.ispartofseriesGRASPen
dc.relation.ispartofseriesv.6en
dc.titleSynthesis of asymmetrically substituted push-pull phthalocyanines as potential photodynamic therapy agenten
dc.typeConference paperen


Files in this item

Icon

This item appears in the following Collection(s)

Show simple item record