Browsing Chemistry by Subject "Acylation"

Now showing items 1-3 of 3

3-(Alkylthio)-N-hydroxysuccinimide derivatives: potent inhibitors of human leukocyte elastase

Groutas, William C.; Venkataraman, Radhika; Brubaker, Michael J.; Epp, Jeffrey B.; Chong, Lee S.; Stanga, Michael A.; McClenahan, Jerald J.; Tagusagawa, F. (Elsevier, 1993-08-07)

A series of 3-(alkylthio)-N-hydroxysuccinimide derivatives was synthesized and their inhibitory activity towards human leukocyte elastase (HLE) was investigated. The interaction of the compounds having a 3-alkylthioether ...
Inhibitors of human neutrophil cathepsin G: structural and biochemical studies

Groutas, William C.; Brubaker, Michael J.; Venkataraman, Radhika; Epp, Jeffrey B.; Stanga, Michael A.; McClenahan, Jerald J. (Elsevier, 1992-04-01)

The interaction of a series of sulfonate and phosphate esters derived from N-hydroxysuccinimide with human leukocyte cathepsin G was investigated. The synthesized compounds were found to be time-dependent inhibitors of the ...
A study of fragmentation of protonated amides of some acylated amino acids by tandem mass spectrometry: observation of an unusual nitrilium ion

Talaty, Erach R.; Young, Sarah M.; Dain, Ryan P.; Van Stipdonk, Michael J. (John Wiley and Sons, 2011-05-15)

A tandem mass spectrometric study of a series of secondary amides of acetylglycine and hippuric acid utilizing electrospray ionization (ESI) was conducted. Among the fragment ions observed was an unusual one, which we have ...