Gutlich, M.; Ziegler, I.; Witter, K.; Hemmens, B.; Hultner, L.; Mcdonald, J. David; Werner, T.; Rodl, W.; Bacher, A.
(Elsevier, 1994-09)
GTP cyclohydrolase I catalyzes the initial and rate limiting step of the biosynthesis of tetrahydrobiopterin, the cofactor for aromatic amino acid hydroxylation. The mouse mutant HPH-1, previously generated by chemical ...