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Browsing BIO Faculty Scholarship by Subject "Female"

Now showing items 1-20 of 23

All-or-none N-glycosylation in primate follicle-stimulating hormone beta-subunits

Bousfield, George R.; Butnev, Vladimir Y.; Walton, Wendy J.; Nguyen, Van T.; Huneidi, Jennifer; Singh, Vinod; Kolli, V. S. Kumar; Harvey, David J.; Rance, Naomi E. (Elsevier Ireland Ltd, 2007-01-02)

Human FSH exists as two major glycoforms designated, tetra-glycosylated and di-glycosylated hFSH. The former possesses both alpha- and beta-subunit carbohydrates while the latter possesses only alpha-subunit carbohydrate. ...
Cardiovascular defects among the progeny of mouse phenylketonuria females

McDonald, J. David; Dyer, Charissa A.; Gailis, Laimonis; Kirby, Margaret L. (Nature Publishing Group, 1997-07)

In a genetic mouse model of human phenylketonuria we have examined the offspring of hyperphenylalaninemic mothers for the presence of cardiovascular defects, an important feature of the pathology of the human maternal ...
Changes in oviducal vascularity during the reproductive cycle of three oviparous lizards (Eumeces obsoletus, Sceloporus undulatus and Crotaphytus collaris)

Masson, G. R.; Guillette, Louis J. (Society for Reproduction and Fertility, 1987-07)

Histologically derived estimates and ink suspension vascular casts were used to examine oviducal vascular changes. Vascularity peaked during gravidity and was correlated with maximal plasma progesterone concentrations. The ...
Characterization of human FSH isoforms reveals a nonglycosylated beta-subunit in addition to the conventional glycosylated beta-subunit

Walton, Wendy J.; Nguyen, Van T.; Butnev, Vladimir Y.; Singh, Vinod; Moore, William T.; Bousfield, George R. (The Endocrine Society, 2001-08)

Human FSH consists of a mixture of isoforms that can be separated on the basis of differences in negative charge conferred by variations in the numbers of sialic acid residues that terminate oligosaccharide branches. Western ...
Characterization of the corticosteroid-binding globulin messenger ribonucleic acid response in the pregnant hamster

Lin, Guang-Xiong; Selcer, Kyle W.; Beale, Elmus G.; Gray, Gray O.; Leavitt, Wendell W. (The Endocrine Society, 1990-10)

In this study we measured corticosteroid-binding globulin (CBG) mRNA levels in liver and various nonhepatic tissues of pregnant and nonpregnant hamsters. The N-terminal amino acid sequence (37 residues) of hamster CBG was ...
Developing a laboratory animal model for perinatal endocrine disruption: the hamster chronicles

Hendry, William J. III; Sheehan, Daniel M.; Khan, Shafiq A.; May, Jeffrey V. (Royal Society of Medicine Press Ltd., 2002-10)

At the biomedical, regulatory, and public level, considerable concern surrounds the concept that inappropriate exposure to endocrine-disrupting chemicals, especially during the prenatal and/or neonatal period, may disrupt ...
Diethylstilbestrol versus estradiol as neonatal disruptors of the hamster (Mesocricetus auratus) cervix

Hendry, William J. III; Branham, William S.; Sheehan, Daniel M. (Society for the Study of Reproduction, 2004-05)

The synthetic estrogen diethylstilbestrol (DES) is an established, estrogenic endocrine disruptor (ED). The Syrian golden hamster (Mesocricetus auratus) offers some unique advantages as an experimental system to investigate ...
Differential activity of diethylstilbestrol versus estradiol as neonatal endocrine disruptors in the female hamster (Mesocricetus auratus) reproductive tract

Hendry, William J. III; DeBrot, Brian L.; Zheng, Xinglong; Branham, William S.; Sheehan, Daniel M. (Society for the Study of Reproduction, 1999-07)

The synthetic estrogen diethylstilbestrol (DES) is a potent neonatal endocrine disruptor in the hamster. To test the specificity of this phenomenon, newborn animals were treated with 100 microgram of either DES or the ...
Diurnal fluctuations in toxicity in two fish species: Gambusia affinis and Notropis ludibundis

Walton, Wendy J.; Brown, Karen Lee; Lydy, Michael J. (Springer New York, 1997-09-01)

The most convenient and direct method for measuring toxic effects of chemicals on organisms is the acute LC50 test. Data obtained from these tests can provide both a rank order of chemical toxicity and relative susceptibilities ...
Effect of maternal blood phenylalanine level on mouse maternal phenylketonuria offspring

Cho, Sangbun; McDonald, J. David (Academic Press, 2001-12)

The genetic mouse model BTBR-Pah(enu2) was used to more thoroughly investigate the pathogenesis of maternal phenylketonuria (MPKU). More specifically, it was used to examine the effect of maternal blood phenylalanine (PHE) ...
Endometrial hyperplasia and apoptosis following neonatal diethylstilbestrol exposure and subsequent estrogen stimulation in both host and transplanted hamster uteri

Hendry, William J. III; Zheng, Xinglong; Leavitt, Wendell W.; Branham, William S.; Sheehan, Daniel M. (American Association for Cancer Research, 1997-05-15)

Prenatal exposure to the synthetic estrogen diethylstilbestrol (DES) causes morphogenetic alterations and neoplasia in the human reproductive tract. In the hamster, neonatal DES exposure alters early uterine morphogenesis ...
Experimental histoplasmosis in the mouse. Immunoglobulin class response, total immunoglobulin A levels, immune complex formation, and occurrence of antigen in serum and urine

Sweet, George H.; Dulohery, Susan M. (American Thoracic Society, 1989-10)

Biotin-avidin enzyme-linked immunosorbent assays (ELISA) were developed to study the appearance of free antibody of the IgM, G, and A classes of immune complexes (IC) containing those classes and of antigen in the serum ...
Feeding evoked by electrical stimulation in collared lizards

Sugerman, Richard A. (Elsevier, 1988)

Feeding was evoked in collared lizards, Crotaphytus collaris, using electrical stimulation of the brain (ESB). Stimulation sites were tested in the forebrain and midbrain of 39 animals. Six stimulation loci were localized ...
Hormone-specific inhibitory influence of alpha-subunit Asn56 oligosaccharide on in vitro subunit association and follicle-stimulating hormone receptor binding of equine gonadotropins

Butnev, Viktor Y.; Gotschall, R. Russell; Butnev, Vladimir Y.; Baker, Vanda L.; Moore, William T.; Bousfield, George R. (Society for the Study of Reproduction, 1998-02-01)

Hybrid hormones were created using combinations of equine (e) LH, eFSH, and eCG alpha- and beta-subunit preparations. The efficiency of eFSH beta association was highest with eLH alpha (64-72%) and was lowest with eCG alpha ...
Increased urotensin I and II immunoreactivity in the urophysis of Gillichthys mirabilis transferred to low salinity water

Larson, B. A.; Madani, Z. (Academic Press, 1991-09)

The function of the fish caudal neurosecretory system is uncertain, but a role in osmoregulation has been suggested by many investigators. Our objective was to determine if acclimation to water of different salinity has ...
Inositol phosphate stimulation by LH requires the entire alpha Asn56 oligosaccharide

Nguyen, Van T.; Singh, Vinod; Butnev, Vladimir Y.; Gray, Ciann M.; Westfall, Suzanne; Davis, John S.; Dias, James A.; Bousfield, George R. (Elsevier Ireland Ltd, 2003-01-31)

Lentil lectin-bound, fucose-enriched hTSH was reported to stimulate both cAMP and inositol phosphate (IP) intracellular signalling pathways, whereas fucose-depleted hTSH stimulated only the cAMP pathway. Gonadotropins ...
Linkage analysis of the hph-1 mutation and the GTP cyclohydrolase I structural gene

Montañez, Cindy S.; McDonald, J. David (Academic Press, 1999-09)

Our research establishes genetic linkage between the hph-1 mutation and the GTP-CH I structural gene. Our results indicate that these two loci are within an 8 cM region with 95% confidence. This finding lends additional ...
Luteal morphology, atresia, and plasma progesterone concentrations during the reproductive cycle of two oviparous lizards, Crotaphytus collaris and Eumeces obsoletus

Fox, Sandra L.; Guillette, Louis J. (John Wiley & Sons, 1987-08)

From ovulation to oviposition, the corpora lutea of the oviparous lizards Crotaphytus collaris and Eumeces obsoletus exhibit three stages of luteal development: 1) luteogenesis, 2) luteal maturity, and 3) luteal regression. ...
Neonatal diethylstilbestrol treatment alters the estrogen-regulated expression of both cell proliferation and apoptosis-related proto-oncogenes (c-jun, c-fos, c-myc, bax, bcl-2, and bcl-x) in the hamster uterus

Zheng, Xinglong; Hendry, William J. III (American Association for Cancer Research, 1997-04)

In the Syrian hamster, neonatal diethylstilbestrol (DES) treatment and then postpubertal estrogen stimulation induces hyperplasia plus apoptosis (preneoplastic responses) and ultimately neoplasia in the endometrial epithelial ...
Postnatal growth in a mouse genetic model of classical phenylketonuria

McDonald, J. David (American Association for Laboratory Animal Science, 2000-11)

Because of the ethical problems of withholding dietary treatment from patients with phenylketonuria, effectively studying long-term effects such as postnatal growth rates is difficult or impossible. The only literature ...